Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells

Nuclear factor-kappaB (NF-kappaB) is a transcription factor that plays a critical role in the inappropriate survival of various types of malignant cells. Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the Western world. Although overexpression and regulation of NF-kappaB...

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Veröffentlicht in:	Oncogene 2007-02, Vol.26 (8), p.1166-1177
Hauptverfasser:	Pickering, B M, de Mel, S, Lee, M, Howell, M, Habens, F, Dallman, C L, Neville, L A, Potter, K N, Mann, J, Mann, D A, Johnson, P W M, Stevenson, F K, Packham, G
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - analysis Aged Antineoplastic Agents - pharmacology Apoptosis B-Lymphocytes - drug effects B-Lymphocytes - metabolism Biomarkers, Tumor - analysis Caspase 3 - analysis Caspase 3 - metabolism Caspase 9 - analysis Caspase 9 - metabolism Cell Nucleus - chemistry Cell Survival - drug effects Cell Survival - genetics Diterpenes - pharmacology Female Gene Expression Regulation, Neoplastic - drug effects Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Male MAP Kinase Kinase 4 - metabolism Middle Aged Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - metabolism NF-kappa B - analysis NF-kappa B - antagonists & inhibitors Nitriles - pharmacology Prognosis Proto-Oncogene Proteins c-bcl-2 - metabolism Sulfones - pharmacology Tumor Cells, Cultured ZAP-70 Protein-Tyrosine Kinase - analysis
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