Reduction of HIV-1 RNA Levels with Therapy to Suppress Herpes Simplex Virus

Coinfection with herpes simplex virus type 2 (HSV-2) in women with HIV-1 infection is associated with increased genital shedding of HIV-1 RNA. In this randomized, double-blind, placebo-controlled trial, suppression of HSV-2 with valacyclovir decreased genital HIV-1 RNA and mean plasma HIV-1 RNA leve...

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Veröffentlicht in:	The New England journal of medicine 2007-02, Vol.356 (8), p.790-799
Hauptverfasser:	Nagot, Nicolas, Ouédraogo, Abdoulaye, Foulongne, Vincent, Konaté, Issouf, Weiss, Helen A, Vergne, Laurence, Defer, Marie-Christine, Djagbaré, Didier, Sanon, Anselme, Andonaba, Jean-Baptiste, Becquart, Pierre, Segondy, Michel, Vallo, Roselyne, Sawadogo, Adrien, Van de Perre, Philippe, Mayaud, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acyclovir - analogs & derivatives Acyclovir - pharmacology Acyclovir - therapeutic use Adolescent Adult AIDS Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences Cervix Uteri - virology Drug therapy Female General aspects Herpes Genitalis - complications Herpes Genitalis - drug therapy Herpes Genitalis - virology Herpes simplex virus 2 Herpesvirus 2, Human - isolation & purification Herpesvirus 2, Human - physiology HIV HIV Infections - complications HIV Infections - virology HIV-1 - drug effects HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Human immunodeficiency virus 2 Human viral diseases Humans Infectious diseases Medical sciences RNA, Viral - analysis RNA, Viral - blood Valacyclovir Valine - analogs & derivatives Valine - pharmacology Valine - therapeutic use Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virus Replication - drug effects Virus Shedding - drug effects Womens health
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