Steroidal saponins from Smilax china and their anti-inflammatory activities

Steroidal saponins 1, 2, 3 and 4 were isolated from Smilax china L. These compounds showed inhibition of cyclooxygenase-2 enzyme (COX-2) activity and mild inhibition of TNFα (tumor necrosis factor α) production. Steroidal saponins, 1, 2, 3 and 4, were isolated from the BuOH extract of Smilax china L...

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Veröffentlicht in:	Phytochemistry (Oxford) 2007-03, Vol.68 (5), p.623-630
Hauptverfasser:	Shao, Bo, Guo, Hongzhu, Cui, Yajun, Ye, Min, Han, Jian, Guo, Dean
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory activities anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology anticarcinogenic activity Biological and medical sciences Carbohydrate Sequence Chemical constitution chemical structure cultured cells Cyclooxygenase 1 Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - isolation & purification Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase-2 enzyme cytotoxicity enzyme inhibition Fundamental and applied biological sciences. Psychology General pharmacology humans Kinetics Liliaceae macrophages Magnetic Resonance Spectroscopy Medical sciences mice Models, Molecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Components, Aerial - chemistry Plant physiology and development Plant Roots - chemistry prostaglandin synthase Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Smilacaceae Smilax Smilax - chemistry Smilax china smilaxchinoside Smilaxchinoside A–D spectral analysis steroid saponins Steroidal saponins Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology Tumor necrosis factor α tumor necrosis factor-alpha
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