Steroidal saponins from Smilax china and their anti-inflammatory activities
Steroidal saponins 1, 2, 3 and 4 were isolated from Smilax china L. These compounds showed inhibition of cyclooxygenase-2 enzyme (COX-2) activity and mild inhibition of TNFα (tumor necrosis factor α) production. Steroidal saponins, 1, 2, 3 and 4, were isolated from the BuOH extract of Smilax china L...
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| Veröffentlicht in: | Phytochemistry (Oxford) 2007-03, Vol.68 (5), p.623-630 |
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| creator | Shao, Bo Guo, Hongzhu Cui, Yajun Ye, Min Han, Jian Guo, Dean |
| description | Steroidal saponins
1,
2,
3 and
4 were isolated from
Smilax china L. These compounds showed inhibition of cyclooxygenase-2 enzyme (COX-2) activity and mild inhibition of TNFα (tumor necrosis factor α) production.
Steroidal saponins,
1,
2,
3 and
4, were isolated from the BuOH extract of
Smilax china L., along with 13 known compounds,
5–
17. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses and chemical evidence. In the bioassay tests, all compounds showed inhibitory effects on cyclooxygenase-2 enzyme (COX-2) activities at final concentration of 10
−5
M, and only compound
5 showed an inhibitory effect on production of TNFα (tumor necrosis factor α) in murine peritoneal macrophages at the same concentration. |
| doi_str_mv | 10.1016/j.phytochem.2006.10.026 |
| format | Article |
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1,
2,
3 and
4 were isolated from
Smilax china L. These compounds showed inhibition of cyclooxygenase-2 enzyme (COX-2) activity and mild inhibition of TNFα (tumor necrosis factor α) production.
Steroidal saponins,
1,
2,
3 and
4, were isolated from the BuOH extract of
Smilax china L., along with 13 known compounds,
5–
17. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses and chemical evidence. In the bioassay tests, all compounds showed inhibitory effects on cyclooxygenase-2 enzyme (COX-2) activities at final concentration of 10
−5
M, and only compound
5 showed an inhibitory effect on production of TNFα (tumor necrosis factor α) in murine peritoneal macrophages at the same concentration.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/j.phytochem.2006.10.026</identifier><identifier>PMID: 17166529</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Anti-inflammatory activities ; anti-inflammatory activity ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; anticarcinogenic activity ; Biological and medical sciences ; Carbohydrate Sequence ; Chemical constitution ; chemical structure ; cultured cells ; Cyclooxygenase 1 ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase 2 Inhibitors - pharmacology ; Cyclooxygenase Inhibitors - chemistry ; Cyclooxygenase Inhibitors - isolation & purification ; Cyclooxygenase Inhibitors - pharmacology ; Cyclooxygenase-2 enzyme ; cytotoxicity ; enzyme inhibition ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; humans ; Kinetics ; Liliaceae ; macrophages ; Magnetic Resonance Spectroscopy ; Medical sciences ; mice ; Models, Molecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Components, Aerial - chemistry ; Plant physiology and development ; Plant Roots - chemistry ; prostaglandin synthase ; Saponins - chemistry ; Saponins - isolation & purification ; Saponins - pharmacology ; Smilacaceae ; Smilax ; Smilax - chemistry ; Smilax china ; smilaxchinoside ; Smilaxchinoside A–D ; spectral analysis ; steroid saponins ; Steroidal saponins ; Steroids - chemistry ; Steroids - isolation & purification ; Steroids - pharmacology ; Tumor necrosis factor α ; tumor necrosis factor-alpha</subject><ispartof>Phytochemistry (Oxford), 2007-03, Vol.68 (5), p.623-630</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-d1182552f3e92e4ac547336996cdb3a183e368f115c33d30929a1be8e56497fc3</citedby><cites>FETCH-LOGICAL-c423t-d1182552f3e92e4ac547336996cdb3a183e368f115c33d30929a1be8e56497fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031942206006856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18583587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17166529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Bo</creatorcontrib><creatorcontrib>Guo, Hongzhu</creatorcontrib><creatorcontrib>Cui, Yajun</creatorcontrib><creatorcontrib>Ye, Min</creatorcontrib><creatorcontrib>Han, Jian</creatorcontrib><creatorcontrib>Guo, Dean</creatorcontrib><title>Steroidal saponins from Smilax china and their anti-inflammatory activities</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>Steroidal saponins
1,
2,
3 and
4 were isolated from
Smilax china L. These compounds showed inhibition of cyclooxygenase-2 enzyme (COX-2) activity and mild inhibition of TNFα (tumor necrosis factor α) production.
Steroidal saponins,
1,
2,
3 and
4, were isolated from the BuOH extract of
Smilax china L., along with 13 known compounds,
5–
17. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses and chemical evidence. In the bioassay tests, all compounds showed inhibitory effects on cyclooxygenase-2 enzyme (COX-2) activities at final concentration of 10
−5
M, and only compound
5 showed an inhibitory effect on production of TNFα (tumor necrosis factor α) in murine peritoneal macrophages at the same concentration.</description><subject>Anti-inflammatory activities</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>anticarcinogenic activity</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Sequence</subject><subject>Chemical constitution</subject><subject>chemical structure</subject><subject>cultured cells</subject><subject>Cyclooxygenase 1</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase 2 Inhibitors - pharmacology</subject><subject>Cyclooxygenase Inhibitors - chemistry</subject><subject>Cyclooxygenase Inhibitors - isolation & purification</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Cyclooxygenase-2 enzyme</subject><subject>cytotoxicity</subject><subject>enzyme inhibition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>humans</subject><subject>Kinetics</subject><subject>Liliaceae</subject><subject>macrophages</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>mice</subject><subject>Models, Molecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Components, Aerial - chemistry</subject><subject>Plant physiology and development</subject><subject>Plant Roots - chemistry</subject><subject>prostaglandin synthase</subject><subject>Saponins - chemistry</subject><subject>Saponins - isolation & purification</subject><subject>Saponins - pharmacology</subject><subject>Smilacaceae</subject><subject>Smilax</subject><subject>Smilax - chemistry</subject><subject>Smilax china</subject><subject>smilaxchinoside</subject><subject>Smilaxchinoside A–D</subject><subject>spectral analysis</subject><subject>steroid saponins</subject><subject>Steroidal saponins</subject><subject>Steroids - chemistry</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><subject>Tumor necrosis factor α</subject><subject>tumor necrosis factor-alpha</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v2zAMQIVhw5pm-wurL9vNmSRasn0siu4DK7BD1rPAyNSiwLYySSmafz8FCdbjTiTIR0p4ZOxG8JXgQn_erfbbYw52S9NKcq5LdcWlfsUWomuhhpbz12zBOYi6b6S8Ytcp7TjnSmn9ll2JVmitZL9gP9aZYvADjlXCfZj9nCoXw1StJz_ic2W3fsYK56HKW_KxZNnXfnYjThPmEI8V2uyffPaU3rE3DsdE7y9xyR6_3P-6-1Y__Pz6_e72obaNhFwPQnRSKemAekkNWtW0ALrvtR02gKIDAt05IZQFGID3skexoY6UbvrWWViyT-e9-xj-HChlM_lkaRxxpnBIRvccWpCigO0ZtDGkFMmZffQTxqMR3Jw8mp3559GcPJ4axWOZ_HB54rCZaHiZu4grwMcLgMni6CLO1qcXrlMdqHKKJbs5cw6Dwd-xMI9ryQVw3irQEgpxeyaoKHvyFE2ynmZLg49ksxmC_-93_wIG8Z52</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Shao, Bo</creator><creator>Guo, Hongzhu</creator><creator>Cui, Yajun</creator><creator>Ye, Min</creator><creator>Han, Jian</creator><creator>Guo, Dean</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Steroidal saponins from Smilax china and their anti-inflammatory activities</title><author>Shao, Bo ; Guo, Hongzhu ; Cui, Yajun ; Ye, Min ; Han, Jian ; Guo, Dean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d1182552f3e92e4ac547336996cdb3a183e368f115c33d30929a1be8e56497fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Anti-inflammatory activities</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>anticarcinogenic activity</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Sequence</topic><topic>Chemical constitution</topic><topic>chemical structure</topic><topic>cultured cells</topic><topic>Cyclooxygenase 1</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase 2 Inhibitors - pharmacology</topic><topic>Cyclooxygenase Inhibitors - chemistry</topic><topic>Cyclooxygenase Inhibitors - isolation & purification</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Cyclooxygenase-2 enzyme</topic><topic>cytotoxicity</topic><topic>enzyme inhibition</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>humans</topic><topic>Kinetics</topic><topic>Liliaceae</topic><topic>macrophages</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>mice</topic><topic>Models, Molecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Components, Aerial - chemistry</topic><topic>Plant physiology and development</topic><topic>Plant Roots - chemistry</topic><topic>prostaglandin synthase</topic><topic>Saponins - chemistry</topic><topic>Saponins - isolation & purification</topic><topic>Saponins - pharmacology</topic><topic>Smilacaceae</topic><topic>Smilax</topic><topic>Smilax - chemistry</topic><topic>Smilax china</topic><topic>smilaxchinoside</topic><topic>Smilaxchinoside A–D</topic><topic>spectral analysis</topic><topic>steroid saponins</topic><topic>Steroidal saponins</topic><topic>Steroids - chemistry</topic><topic>Steroids - isolation & purification</topic><topic>Steroids - pharmacology</topic><topic>Tumor necrosis factor α</topic><topic>tumor necrosis factor-alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shao, Bo</creatorcontrib><creatorcontrib>Guo, Hongzhu</creatorcontrib><creatorcontrib>Cui, Yajun</creatorcontrib><creatorcontrib>Ye, Min</creatorcontrib><creatorcontrib>Han, Jian</creatorcontrib><creatorcontrib>Guo, Dean</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shao, Bo</au><au>Guo, Hongzhu</au><au>Cui, Yajun</au><au>Ye, Min</au><au>Han, Jian</au><au>Guo, Dean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steroidal saponins from Smilax china and their anti-inflammatory activities</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>68</volume><issue>5</issue><spage>623</spage><epage>630</epage><pages>623-630</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>Steroidal saponins
1,
2,
3 and
4 were isolated from
Smilax china L. These compounds showed inhibition of cyclooxygenase-2 enzyme (COX-2) activity and mild inhibition of TNFα (tumor necrosis factor α) production.
Steroidal saponins,
1,
2,
3 and
4, were isolated from the BuOH extract of
Smilax china L., along with 13 known compounds,
5–
17. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses and chemical evidence. In the bioassay tests, all compounds showed inhibitory effects on cyclooxygenase-2 enzyme (COX-2) activities at final concentration of 10
−5
M, and only compound
5 showed an inhibitory effect on production of TNFα (tumor necrosis factor α) in murine peritoneal macrophages at the same concentration.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>17166529</pmid><doi>10.1016/j.phytochem.2006.10.026</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9422 |
| ispartof | Phytochemistry (Oxford), 2007-03, Vol.68 (5), p.623-630 |
| issn | 0031-9422 1873-3700 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anti-inflammatory activities anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology anticarcinogenic activity Biological and medical sciences Carbohydrate Sequence Chemical constitution chemical structure cultured cells Cyclooxygenase 1 Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - isolation & purification Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase-2 enzyme cytotoxicity enzyme inhibition Fundamental and applied biological sciences. Psychology General pharmacology humans Kinetics Liliaceae macrophages Magnetic Resonance Spectroscopy Medical sciences mice Models, Molecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Components, Aerial - chemistry Plant physiology and development Plant Roots - chemistry prostaglandin synthase Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Smilacaceae Smilax Smilax - chemistry Smilax china smilaxchinoside Smilaxchinoside A–D spectral analysis steroid saponins Steroidal saponins Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology Tumor necrosis factor α tumor necrosis factor-alpha |
| title | Steroidal saponins from Smilax china and their anti-inflammatory activities |
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