A Role for ATP-Citrate Lyase, Malic Enzyme, and Pyruvate/Citrate Cycling in Glucose-induced Insulin Secretion

In pancreatic β-cells, metabolic coupling factors generated during glucose metabolism and pyruvate cycling through anaplerosis/cataplerosis processes contribute to the regulation of insulin secretion. Pyruvate/citrate cycling across the mitochondrial membrane leads to the production of malonyl-CoA a...

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Veröffentlicht in:	The Journal of biological chemistry 2007-12, Vol.282 (49), p.35657-35665
Hauptverfasser:	Guay, Claudiane, Madiraju, S.R. Murthy, Aumais, Alexandre, Joly, Érik, Prentki, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Citrate (pro-S)-Lyase - antagonists & inhibitors ATP Citrate (pro-S)-Lyase - genetics ATP Citrate (pro-S)-Lyase - metabolism Cell Line Citric Acid - metabolism Enzyme Inhibitors - pharmacology Glucose - metabolism Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - metabolism Macrolides - pharmacology Malate Dehydrogenase - antagonists & inhibitors Malate Dehydrogenase - genetics Malate Dehydrogenase - metabolism Malonyl Coenzyme A - metabolism Mitochondrial Membranes - metabolism NADP - metabolism Pyruvic Acid - metabolism Rats RNA Interference Signal Transduction - drug effects Signal Transduction - physiology
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