Pertussis toxin transiently affects barrier integrity, organelle organization and transmigration of monocytes in a human brain microvascular endothelial cell barrier model

Encephalopathies and neurological disorders are sometimes associated with respiratory tract infections caused by Bordetella pertussis. For these complications to occur cerebral barriers have to be compromised. Therefore, the influence of pertussis toxin (PT), a decisive virulence determinant of B. p...

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Veröffentlicht in:	Cellular microbiology 2007-03, Vol.9 (3), p.619-632
Hauptverfasser:	Kügler, Silke, Böcker, Kathrin, Heusipp, Gerhard, Greune, Lilo, Kim, Kwang Sik, Schmidt, M. Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood-Brain Barrier - cytology Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blotting, Western Bordetella pertussis Capillary Permeability - drug effects Cell Movement - drug effects Cells, Cultured Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - ultrastructure Golgi Apparatus - drug effects Golgi Apparatus - metabolism Golgi Apparatus - ultrastructure Humans Lysosomes - metabolism Microscopy, Electron, Transmission Models, Neurological Monocytes - drug effects Monocytes - metabolism Monocytes - ultrastructure Pertussis Toxin - pharmacology Signal Transduction - drug effects
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