Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tumor tissues (NT) from 40 patients were analyze...
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| Veröffentlicht in: | Experimental & molecular medicine 2007-10, Vol.39 (5), p.641-652 |
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| creator | Yu, Gyung Ran Kim, Seong Hun Park, Seon Hwa Cui, Xiang Dan Xu, Dong Yuan Yu, Hee Chul Cho, Baik Hwan Yeom, Young Il Kim, Sang Soo Kim, Sang Bae Chu, In Sun Kim, Dae Ghon |
| description | The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tumor tissues (NT) from 40 patients were analyzed. Of total 217 genes, 72 were expressed preferentially in HCC tissues. Among 186 differentially regulated genes, there were molecular chaperone and tumor suppressor gene clusters in the Edmondson grades I and II (GI/II) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P=0.0133) contained 122 differentially regulated genes with a cluster containing various metastasis- and invasion-related genes compared with the GI/II subclass. Immunohistochemical analysis revealed that ANXA2, one of the 72 genes preferentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses will be useful molecular markers for the genesis and progression of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC. |
| doi_str_mv | 10.1038/emm.2007.70 |
| format | Article |
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Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tumor tissues (NT) from 40 patients were analyzed. Of total 217 genes, 72 were expressed preferentially in HCC tissues. Among 186 differentially regulated genes, there were molecular chaperone and tumor suppressor gene clusters in the Edmondson grades I and II (GI/II) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P=0.0133) contained 122 differentially regulated genes with a cluster containing various metastasis- and invasion-related genes compared with the GI/II subclass. Immunohistochemical analysis revealed that ANXA2, one of the 72 genes preferentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses will be useful molecular markers for the genesis and progression of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC.</description><identifier>ISSN: 1226-3613</identifier><identifier>ISSN: 2092-6413</identifier><identifier>EISSN: 2092-6413</identifier><identifier>DOI: 10.1038/emm.2007.70</identifier><identifier>PMID: 18059140</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Annexin A2 - genetics ; Biomarkers, Tumor - genetics ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - pathology ; Gene Expression Profiling ; Genes, Tumor Suppressor ; Humans ; Liver Neoplasms - genetics ; Liver Neoplasms - pathology ; Molecular Chaperones - genetics ; Multigene Family ; Oligonucleotide Array Sequence Analysis ; Oncogenes</subject><ispartof>Experimental & molecular medicine, 2007-10, Vol.39 (5), p.641-652</ispartof><rights>Copyright Nature Publishing Group Oct 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-2e730dddfbb181b58d18f4671c1779413eb13722dbdfb2242a7d4e08e040984f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18059140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Gyung Ran</creatorcontrib><creatorcontrib>Kim, Seong Hun</creatorcontrib><creatorcontrib>Park, Seon Hwa</creatorcontrib><creatorcontrib>Cui, Xiang Dan</creatorcontrib><creatorcontrib>Xu, Dong Yuan</creatorcontrib><creatorcontrib>Yu, Hee Chul</creatorcontrib><creatorcontrib>Cho, Baik Hwan</creatorcontrib><creatorcontrib>Yeom, Young Il</creatorcontrib><creatorcontrib>Kim, Sang Soo</creatorcontrib><creatorcontrib>Kim, Sang Bae</creatorcontrib><creatorcontrib>Chu, In Sun</creatorcontrib><creatorcontrib>Kim, Dae Ghon</creatorcontrib><title>Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma</title><title>Experimental & molecular medicine</title><addtitle>Exp Mol Med</addtitle><description>The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tumor tissues (NT) from 40 patients were analyzed. Of total 217 genes, 72 were expressed preferentially in HCC tissues. Among 186 differentially regulated genes, there were molecular chaperone and tumor suppressor gene clusters in the Edmondson grades I and II (GI/II) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P=0.0133) contained 122 differentially regulated genes with a cluster containing various metastasis- and invasion-related genes compared with the GI/II subclass. Immunohistochemical analysis revealed that ANXA2, one of the 72 genes preferentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses will be useful molecular markers for the genesis and progression of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC.</description><subject>Annexin A2 - genetics</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Gene Expression Profiling</subject><subject>Genes, Tumor Suppressor</subject><subject>Humans</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - pathology</subject><subject>Molecular Chaperones - genetics</subject><subject>Multigene Family</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncogenes</subject><issn>1226-3613</issn><issn>2092-6413</issn><issn>2092-6413</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtLxTAUhIMoen2s3EtBEEF6PXm0SZcivkBwo-uSJidabZtr0i7896Z6UXDh6my-Gc7MEHJIYUmBq3Ps-yUDkEsJG2TBoGJ5KSjfJAvKWJnzkvIdshvjKwArhBTbZIcqKCoqYEH0ncVhbF1r9Nj6IfMu632HZup0yHod3jDEzPmQjS-Y-cH4Zxxak9nWOQyz8kf2gis9eoNd96U1Oph28L3eJ1tOdxEP1nePPF1fPV7e5vcPN3eXF_e54aoYc4aSg7XWNQ1VtCmUpcqJUlJDpaxSHmwol4zZJiGMCaalFQgKQUClhON75OTbdxX8-4RxrPs2zu_oAf0U67ICLiouE3j6L0iVKHkleMESevwHffVTGFKMRAGI1G85G559Uyb4GAO6ehXa1N1HTaGeJ6rTRPU8US0h0Udrz6np0f6y6034Jw7fjH4</recordid><startdate>20071031</startdate><enddate>20071031</enddate><creator>Yu, Gyung Ran</creator><creator>Kim, Seong Hun</creator><creator>Park, Seon Hwa</creator><creator>Cui, Xiang Dan</creator><creator>Xu, Dong Yuan</creator><creator>Yu, Hee Chul</creator><creator>Cho, Baik Hwan</creator><creator>Yeom, Young Il</creator><creator>Kim, Sang Soo</creator><creator>Kim, Sang Bae</creator><creator>Chu, In Sun</creator><creator>Kim, Dae Ghon</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20071031</creationdate><title>Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma</title><author>Yu, Gyung Ran ; Kim, Seong Hun ; Park, Seon Hwa ; Cui, Xiang Dan ; Xu, Dong Yuan ; Yu, Hee Chul ; Cho, Baik Hwan ; Yeom, Young Il ; Kim, Sang Soo ; Kim, Sang Bae ; Chu, In Sun ; Kim, Dae Ghon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-2e730dddfbb181b58d18f4671c1779413eb13722dbdfb2242a7d4e08e040984f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Annexin A2 - genetics</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Gene Expression Profiling</topic><topic>Genes, Tumor Suppressor</topic><topic>Humans</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - pathology</topic><topic>Molecular Chaperones - genetics</topic><topic>Multigene Family</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncogenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Gyung Ran</creatorcontrib><creatorcontrib>Kim, Seong Hun</creatorcontrib><creatorcontrib>Park, Seon Hwa</creatorcontrib><creatorcontrib>Cui, Xiang Dan</creatorcontrib><creatorcontrib>Xu, Dong Yuan</creatorcontrib><creatorcontrib>Yu, Hee Chul</creatorcontrib><creatorcontrib>Cho, Baik Hwan</creatorcontrib><creatorcontrib>Yeom, Young Il</creatorcontrib><creatorcontrib>Kim, Sang Soo</creatorcontrib><creatorcontrib>Kim, Sang Bae</creatorcontrib><creatorcontrib>Chu, In Sun</creatorcontrib><creatorcontrib>Kim, Dae Ghon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental & molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Gyung Ran</au><au>Kim, Seong Hun</au><au>Park, Seon Hwa</au><au>Cui, Xiang Dan</au><au>Xu, Dong Yuan</au><au>Yu, Hee Chul</au><au>Cho, Baik Hwan</au><au>Yeom, Young Il</au><au>Kim, Sang Soo</au><au>Kim, Sang Bae</au><au>Chu, In Sun</au><au>Kim, Dae Ghon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma</atitle><jtitle>Experimental & molecular medicine</jtitle><addtitle>Exp Mol Med</addtitle><date>2007-10-31</date><risdate>2007</risdate><volume>39</volume><issue>5</issue><spage>641</spage><epage>652</epage><pages>641-652</pages><issn>1226-3613</issn><issn>2092-6413</issn><eissn>2092-6413</eissn><abstract>The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tumor tissues (NT) from 40 patients were analyzed. Of total 217 genes, 72 were expressed preferentially in HCC tissues. Among 186 differentially regulated genes, there were molecular chaperone and tumor suppressor gene clusters in the Edmondson grades I and II (GI/II) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P=0.0133) contained 122 differentially regulated genes with a cluster containing various metastasis- and invasion-related genes compared with the GI/II subclass. Immunohistochemical analysis revealed that ANXA2, one of the 72 genes preferentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses will be useful molecular markers for the genesis and progression of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>18059140</pmid><doi>10.1038/emm.2007.70</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Annexin A2 - genetics Biomarkers, Tumor - genetics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Gene Expression Profiling Genes, Tumor Suppressor Humans Liver Neoplasms - genetics Liver Neoplasms - pathology Molecular Chaperones - genetics Multigene Family Oligonucleotide Array Sequence Analysis Oncogenes |
| title | Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma |
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