Monocytosis in BXSB mice is due to epistasis between Yaa and the telomeric region of Chromosome 1 but does not drive the disease process

The BXSB murine model of systemic lupus erythematosus is differentiated from other murine models of lupus by a severe monocytosis. The recently identified Y-linked autoimmune accelerator locus, Yaa , which is fundamental to accelerated disease in male BXSB mice, is required for the monocytic phenoty...

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Veröffentlicht in:	Genes and immunity 2007-12, Vol.8 (8), p.619-627
Hauptverfasser:	Rogers, N J, Gabriel, L, Nunes, C T, Rose, S J, Thiruudaian, V, Boyle, J, Morley, B J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Autoantibodies Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow - drug effects Bone Marrow - immunology Cancer Research CD11b Antigen - analysis Chromosome 1 Chromosomes Chromosomes - genetics Epigenesis, Genetic Epistasis Gene Expression Genes Genetic aspects Genotype & phenotype Glomerulonephritis Health aspects Human Genetics Immunology Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus nephritis Macrophage Colony-Stimulating Factor - pharmacology Male Mice Mice, Congenic Monocytes Monocytes - immunology Monocytosis Nephritis original-article Pathogenicity Pathology Phenotypes Physiological aspects Risk factors Spleen - immunology Systemic lupus erythematosus Telomere - genetics
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