Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action
Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction of T. foenum-graecum were evaluated. Administration of SDF fraction (0·5 g/kg body weight) to no...
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| Veröffentlicht in: | British journal of nutrition 2007-03, Vol.97 (3), p.514-521 |
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| container_title | British journal of nutrition |
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| creator | Hannan, J. M. A. Ali, L. Rokeya, B. Khaleque, J. Akhter, M. Flatt, P. R. Abdel-Wahab, Y. H. A. |
| description | Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction of T. foenum-graecum were evaluated. Administration of SDF fraction (0·5 g/kg body weight) to normal, type 1 or type 2 diabetic rats significantly improved oral glucose tolerance. Total remaining unabsorbed sucrose in the gastrointestinal tract of non-diabetic and type 2 diabetic rats, following oral sucrose loading (2·5 g/kg body weight) was significantly increased by T. foenum-graecum (0·5 g/kg body weight). The SDF fraction suppressed the elevation of blood glucose after oral sucrose ingestion in both non-diabetic and type 2 diabetic rats. Intestinal disaccharidase activity and glucose absorption were decreased and gastrointestinal motility increased by the SDF fraction. Daily oral administration of SDF to type 2 diabetic rats for 28 d decreased serum glucose, increased liver glycogen content and enhanced total antioxidant status. Serum insulin and insulin secretion were not affected by the SDF fraction. Glucose transport in 3T3-L1 adipocytes and insulin action were increased by T. foenum-graecum. The present findings indicate that the SDF fraction of T. foenum-graecum seeds exerts antidiabetic effects mediated through inhibition of carbohydrate digestion and absorption, and enhancement of peripheral insulin action. |
| doi_str_mv | 10.1017/S0007114507657869 |
| format | Article |
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M. A. ; Ali, L. ; Rokeya, B. ; Khaleque, J. ; Akhter, M. ; Flatt, P. R. ; Abdel-Wahab, Y. H. A.</creator><creatorcontrib>Hannan, J. M. A. ; Ali, L. ; Rokeya, B. ; Khaleque, J. ; Akhter, M. ; Flatt, P. R. ; Abdel-Wahab, Y. H. A.</creatorcontrib><description>Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction of T. foenum-graecum were evaluated. Administration of SDF fraction (0·5 g/kg body weight) to normal, type 1 or type 2 diabetic rats significantly improved oral glucose tolerance. Total remaining unabsorbed sucrose in the gastrointestinal tract of non-diabetic and type 2 diabetic rats, following oral sucrose loading (2·5 g/kg body weight) was significantly increased by T. foenum-graecum (0·5 g/kg body weight). The SDF fraction suppressed the elevation of blood glucose after oral sucrose ingestion in both non-diabetic and type 2 diabetic rats. Intestinal disaccharidase activity and glucose absorption were decreased and gastrointestinal motility increased by the SDF fraction. Daily oral administration of SDF to type 2 diabetic rats for 28 d decreased serum glucose, increased liver glycogen content and enhanced total antioxidant status. Serum insulin and insulin secretion were not affected by the SDF fraction. Glucose transport in 3T3-L1 adipocytes and insulin action were increased by T. foenum-graecum. The present findings indicate that the SDF fraction of T. foenum-graecum seeds exerts antidiabetic effects mediated through inhibition of carbohydrate digestion and absorption, and enhancement of peripheral insulin action.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114507657869</identifier><identifier>PMID: 17313713</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Absorption ; Adipocytes ; Animal models ; Animals ; Biological and medical sciences ; blood glucose ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Body weight ; carbohydrate metabolism ; Carbohydrates ; Diabetes ; Diabetes mellitus (insulin dependent) ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - diet therapy ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - diet therapy ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - diet therapy ; Diabetes Mellitus, Type 2 - physiopathology ; Dietary Carbohydrates - pharmacokinetics ; Dietary fiber ; Dietary Fiber - pharmacology ; Dietary Fiber - therapeutic use ; Digestion ; Digestion - drug effects ; Disaccharidases - antagonists & inhibitors ; Disaccharidases - metabolism ; Feeding. Feeding behavior ; Fenugreek ; fiber content ; Fundamental and applied biological sciences. Psychology ; Gastric motility ; Gastrointestinal motility ; Gastrointestinal Motility - drug effects ; Gastrointestinal system ; Gastrointestinal tract ; Glucose ; Glucose absorption ; Glucose tolerance ; Glucose transport ; Glycogen ; Glycogens ; Homeostasis ; Homeostasis - drug effects ; hypoglycemic agents ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Ingestion ; Insulin ; Insulin - metabolism ; Insulin action ; Insulin Secretion ; insulin-dependent diabetes mellitus ; intestinal absorption ; Intestinal Absorption - drug effects ; Intestine, Small - enzymology ; Male ; medicinal properties ; Motility ; noninsulin-dependent diabetes mellitus ; Oral administration ; Rats ; Rats, Long-Evans ; Rodents ; Seeds ; Small intestine ; Solubility ; Soluble dietary fibre ; Sucrose ; Sucrose - pharmacokinetics ; Trigonella - chemistry ; Trigonella foenum-graecum ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2007-03, Vol.97 (3), p.514-521</ispartof><rights>Copyright © The Authors 2007</rights><rights>2007 INIST-CNRS</rights><rights>The Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-e85a6b421f172f655fbbfde0f99c5403a8b7d2be933a2d7e343b8f75cc184c9b3</citedby><cites>FETCH-LOGICAL-c490t-e85a6b421f172f655fbbfde0f99c5403a8b7d2be933a2d7e343b8f75cc184c9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114507657869/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18539158$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17313713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hannan, J. M. A.</creatorcontrib><creatorcontrib>Ali, L.</creatorcontrib><creatorcontrib>Rokeya, B.</creatorcontrib><creatorcontrib>Khaleque, J.</creatorcontrib><creatorcontrib>Akhter, M.</creatorcontrib><creatorcontrib>Flatt, P. R.</creatorcontrib><creatorcontrib>Abdel-Wahab, Y. H. A.</creatorcontrib><title>Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction of T. foenum-graecum were evaluated. Administration of SDF fraction (0·5 g/kg body weight) to normal, type 1 or type 2 diabetic rats significantly improved oral glucose tolerance. Total remaining unabsorbed sucrose in the gastrointestinal tract of non-diabetic and type 2 diabetic rats, following oral sucrose loading (2·5 g/kg body weight) was significantly increased by T. foenum-graecum (0·5 g/kg body weight). The SDF fraction suppressed the elevation of blood glucose after oral sucrose ingestion in both non-diabetic and type 2 diabetic rats. Intestinal disaccharidase activity and glucose absorption were decreased and gastrointestinal motility increased by the SDF fraction. Daily oral administration of SDF to type 2 diabetic rats for 28 d decreased serum glucose, increased liver glycogen content and enhanced total antioxidant status. Serum insulin and insulin secretion were not affected by the SDF fraction. Glucose transport in 3T3-L1 adipocytes and insulin action were increased by T. foenum-graecum. The present findings indicate that the SDF fraction of T. foenum-graecum seeds exerts antidiabetic effects mediated through inhibition of carbohydrate digestion and absorption, and enhancement of peripheral insulin action.</description><subject>Absorption</subject><subject>Adipocytes</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood glucose</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Body weight</subject><subject>carbohydrate metabolism</subject><subject>Carbohydrates</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - diet therapy</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - diet therapy</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - diet therapy</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Dietary Carbohydrates - pharmacokinetics</subject><subject>Dietary fiber</subject><subject>Dietary Fiber - pharmacology</subject><subject>Dietary Fiber - therapeutic use</subject><subject>Digestion</subject><subject>Digestion - drug effects</subject><subject>Disaccharidases - antagonists & inhibitors</subject><subject>Disaccharidases - metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Fenugreek</subject><subject>fiber content</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric motility</subject><subject>Gastrointestinal motility</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Glucose</subject><subject>Glucose absorption</subject><subject>Glucose tolerance</subject><subject>Glucose transport</subject><subject>Glycogen</subject><subject>Glycogens</subject><subject>Homeostasis</subject><subject>Homeostasis - drug effects</subject><subject>hypoglycemic agents</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Ingestion</subject><subject>Insulin</subject><subject>Insulin - metabolism</subject><subject>Insulin action</subject><subject>Insulin Secretion</subject><subject>insulin-dependent diabetes mellitus</subject><subject>intestinal absorption</subject><subject>Intestinal Absorption - drug effects</subject><subject>Intestine, Small - enzymology</subject><subject>Male</subject><subject>medicinal properties</subject><subject>Motility</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Oral administration</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Rodents</subject><subject>Seeds</subject><subject>Small intestine</subject><subject>Solubility</subject><subject>Soluble dietary fibre</subject><subject>Sucrose</subject><subject>Sucrose - pharmacokinetics</subject><subject>Trigonella - chemistry</subject><subject>Trigonella foenum-graecum</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kt1u1DAQhSMEokvhAbgBqwgEEgE7juPkEirYIirxs9try3bGWbdJvNgJIm_MY-DsrlgJ1CtnMt8cnxlPkjwm-A3BhL9dYYw5ITnDvGC8LKo7yYLknKVZUWR3k8WcTuf8SfIghOsYlgRX95MTwimhnNBF8nvl2lG1gGoLg_QTMlZ5QMZLPVjXI2fQ2tvG9dC2EhkH_diljZegxw69NDFsPMDNKxQAamS7rXc_IaCmHbULgDauAxcGGWxAtkeyt51sUedqaMOsPUxbQCT-r_efWfQhFQxRQk0oUnKyfYO09MptptrLYXbaQNiZm8ukCs5v5_D1LoZ-I3s9F9k-jO186a6Th8k9I9sAjw7naXL18cP6_CK9_LL8dP7uMtV5hYcUSiYLlWfEEJ6ZgjGjlKkBm6rSLMdUlorXmYKKUpnVHGhOVWk405qUua4UPU1e7HXjJH6M0ajobNDz9HpwYxBFhWmeZTyCz_4Br93o--hNZCVl8aVIVUXq7FaK0JJizmmEyB7S3oXgwYitj4P2kyBYzJsi_tuUWPPkIDyqDupjxWE1IvD8AMigZRs3Io41HLmS0YqwMnLpnrNhgF9_89LfiIJTzkSx_CaWefX-4vv6s_ga-ad73kgnZOOj5tUqw4RGhwXnWREJemhHdsrbuoFj07c39AeN6_HH</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Hannan, J. 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M. A. ; Ali, L. ; Rokeya, B. ; Khaleque, J. ; Akhter, M. ; Flatt, P. R. ; Abdel-Wahab, Y. H. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-e85a6b421f172f655fbbfde0f99c5403a8b7d2be933a2d7e343b8f75cc184c9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Absorption</topic><topic>Adipocytes</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood glucose</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Body weight</topic><topic>carbohydrate metabolism</topic><topic>Carbohydrates</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - diet therapy</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - diet therapy</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - diet therapy</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Dietary Carbohydrates - pharmacokinetics</topic><topic>Dietary fiber</topic><topic>Dietary Fiber - pharmacology</topic><topic>Dietary Fiber - therapeutic use</topic><topic>Digestion</topic><topic>Digestion - drug effects</topic><topic>Disaccharidases - antagonists & inhibitors</topic><topic>Disaccharidases - metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Fenugreek</topic><topic>fiber content</topic><topic>Fundamental and applied biological sciences. 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M. A.</au><au>Ali, L.</au><au>Rokeya, B.</au><au>Khaleque, J.</au><au>Akhter, M.</au><au>Flatt, P. R.</au><au>Abdel-Wahab, Y. H. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>97</volume><issue>3</issue><spage>514</spage><epage>521</epage><pages>514-521</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction of T. foenum-graecum were evaluated. Administration of SDF fraction (0·5 g/kg body weight) to normal, type 1 or type 2 diabetic rats significantly improved oral glucose tolerance. Total remaining unabsorbed sucrose in the gastrointestinal tract of non-diabetic and type 2 diabetic rats, following oral sucrose loading (2·5 g/kg body weight) was significantly increased by T. foenum-graecum (0·5 g/kg body weight). The SDF fraction suppressed the elevation of blood glucose after oral sucrose ingestion in both non-diabetic and type 2 diabetic rats. Intestinal disaccharidase activity and glucose absorption were decreased and gastrointestinal motility increased by the SDF fraction. Daily oral administration of SDF to type 2 diabetic rats for 28 d decreased serum glucose, increased liver glycogen content and enhanced total antioxidant status. Serum insulin and insulin secretion were not affected by the SDF fraction. Glucose transport in 3T3-L1 adipocytes and insulin action were increased by T. foenum-graecum. The present findings indicate that the SDF fraction of T. foenum-graecum seeds exerts antidiabetic effects mediated through inhibition of carbohydrate digestion and absorption, and enhancement of peripheral insulin action.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>17313713</pmid><doi>10.1017/S0007114507657869</doi><tpages>8</tpages></addata></record> |
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| ispartof | British journal of nutrition, 2007-03, Vol.97 (3), p.514-521 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69034227 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry; Cambridge University Press Journals Complete |
| subjects | Absorption Adipocytes Animal models Animals Biological and medical sciences blood glucose Blood Glucose - drug effects Blood Glucose - metabolism Body weight carbohydrate metabolism Carbohydrates Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - diet therapy Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - diet therapy Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diet therapy Diabetes Mellitus, Type 2 - physiopathology Dietary Carbohydrates - pharmacokinetics Dietary fiber Dietary Fiber - pharmacology Dietary Fiber - therapeutic use Digestion Digestion - drug effects Disaccharidases - antagonists & inhibitors Disaccharidases - metabolism Feeding. Feeding behavior Fenugreek fiber content Fundamental and applied biological sciences. Psychology Gastric motility Gastrointestinal motility Gastrointestinal Motility - drug effects Gastrointestinal system Gastrointestinal tract Glucose Glucose absorption Glucose tolerance Glucose transport Glycogen Glycogens Homeostasis Homeostasis - drug effects hypoglycemic agents Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Ingestion Insulin Insulin - metabolism Insulin action Insulin Secretion insulin-dependent diabetes mellitus intestinal absorption Intestinal Absorption - drug effects Intestine, Small - enzymology Male medicinal properties Motility noninsulin-dependent diabetes mellitus Oral administration Rats Rats, Long-Evans Rodents Seeds Small intestine Solubility Soluble dietary fibre Sucrose Sucrose - pharmacokinetics Trigonella - chemistry Trigonella foenum-graecum Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T03%3A01%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Soluble%20dietary%20fibre%20fraction%20of%20Trigonella%20foenum-graecum%20(fenugreek)%20seed%20improves%20glucose%20homeostasis%20in%20animal%20models%20of%20type%201%20and%20type%202%20diabetes%20by%20delaying%20carbohydrate%20digestion%20and%20absorption,%20and%20enhancing%20insulin%20action&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Hannan,%20J.%20M.%20A.&rft.date=2007-03-01&rft.volume=97&rft.issue=3&rft.spage=514&rft.epage=521&rft.pages=514-521&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114507657869&rft_dat=%3Cproquest_cross%3E1889093951%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213830773&rft_id=info:pmid/17313713&rft_cupid=10_1017_S0007114507657869&rfr_iscdi=true |