Protein Oxidative Modifications and Replicative Senescence of WI-38 Human Embryonic Fibroblasts

: The age‐related accumulation of oxidized proteins is dependent on the balance between the generation of oxidatively modified proteins and their elimination by protein degradation and repair systems. Previous studies have demonstrated that replicative senescence represents a valid model of in vitr...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2007-11, Vol.1119 (1), p.88-96
Hauptverfasser:	AHMED, EMAD KHAIRY, PICOT, CÉDRIC R., BULTEAU, ANNE-LAURE, FRIGUET, BERTRAND
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aldehydes - metabolism Catalytic Domain Cellular Senescence Cross-Linking Reagents - metabolism Cysteine Proteinase Inhibitors - metabolism Embryo, Mammalian - enzymology Embryo, Mammalian - pathology Fibroblasts - enzymology Fibroblasts - pathology Gene Expression Regulation, Enzymologic Humans Lipid Peroxidation lipid peroxidation adducts Oxidation-Reduction Proteasome Endopeptidase Complex - biosynthesis Proteasome Inhibitors protein glycoxidation protein oxidation Protein Processing, Post-Translational replicative senescence
Online-Zugang:	Volltext
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