Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8 CD3 count reconstitution is associated with survival
To evaluate the correlation between kinetics of immune reconstitution and survival, we prospectively evaluated lymphocyte subsets in 32 paediatric patients undergoing allogeneic stem cell transplantation (SCT) for haematological malignancies. Four-colour flow cytometric analysis was performed at sho...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2007-03, Vol.39 (5), p.269-278 |
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| creator | KOEHL, U BOCHENNEK, K ORTH, A BADER, P SCHWABE, D KLINGEBIEL, T ZIMMERMANN, S. Y LEHRNBECHER, T SÖRENSEN, J ESSER, R ANDREAS, C KRAMM, C GRÜTTNER, H. P FALKENBERG, E |
| description | To evaluate the correlation between kinetics of immune reconstitution and survival, we prospectively evaluated lymphocyte subsets in 32 paediatric patients undergoing allogeneic stem cell transplantation (SCT) for haematological malignancies. Four-colour flow cytometric analysis was performed at short intervals with a median follow-up of 4 years post SCT. A total of 50% of patients reached age-matched 5th percentile of natural killer, cytotoxic T, B and helper T cells 4, 9, 20 and 28 weeks after SCT, respectively, which increased to more than 80% within 1 year after SCT. Transplantation of peripheral blood stem cells (PBSC) seemed to elicit the fastest reconstitution of CD3+, CD4+ CD3+, CD8+ CD3+ and naïve T cells compared to bone marrow (BM) or CD34-selected PBSC, which did not differ. Most importantly, we observed a significantly higher number of survivors among patients whose CD8+ CD3+ absolute counts rose above the 5th percentile of age-matched normal levels during the first year post SCT compared to patients who never reached these levels (19/25 vs 0/7, P |
| doi_str_mv | 10.1038/sj.bmt.1705584 |
| format | Article |
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Y ; LEHRNBECHER, T ; SÖRENSEN, J ; ESSER, R ; ANDREAS, C ; KRAMM, C ; GRÜTTNER, H. P ; FALKENBERG, E</creator><creatorcontrib>KOEHL, U ; BOCHENNEK, K ; ORTH, A ; BADER, P ; SCHWABE, D ; KLINGEBIEL, T ; ZIMMERMANN, S. Y ; LEHRNBECHER, T ; SÖRENSEN, J ; ESSER, R ; ANDREAS, C ; KRAMM, C ; GRÜTTNER, H. P ; FALKENBERG, E</creatorcontrib><description>To evaluate the correlation between kinetics of immune reconstitution and survival, we prospectively evaluated lymphocyte subsets in 32 paediatric patients undergoing allogeneic stem cell transplantation (SCT) for haematological malignancies. Four-colour flow cytometric analysis was performed at short intervals with a median follow-up of 4 years post SCT. A total of 50% of patients reached age-matched 5th percentile of natural killer, cytotoxic T, B and helper T cells 4, 9, 20 and 28 weeks after SCT, respectively, which increased to more than 80% within 1 year after SCT. Transplantation of peripheral blood stem cells (PBSC) seemed to elicit the fastest reconstitution of CD3+, CD4+ CD3+, CD8+ CD3+ and naïve T cells compared to bone marrow (BM) or CD34-selected PBSC, which did not differ. Most importantly, we observed a significantly higher number of survivors among patients whose CD8+ CD3+ absolute counts rose above the 5th percentile of age-matched normal levels during the first year post SCT compared to patients who never reached these levels (19/25 vs 0/7, P<0.001). This was still present in both subgroups, BM- and CD34-selected grafts (P=0.03, 0.02). These results from a small patient sample underline the importance of particular lymphocyte subsets for the outcome of children undergoing SCT. A larger study with detailed subset analysis is underway.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1705584</identifier><identifier>PMID: 17311085</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adolescent ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone marrow ; Bone Marrow Cells ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Care and treatment ; CD3 antigen ; CD3 Complex - immunology ; CD34 antigen ; CD4 antigen ; CD4-Positive T-Lymphocytes ; CD8 antigen ; CD8 Antigens - immunology ; CD8-Positive T-Lymphocytes - immunology ; Child ; Child, Preschool ; Children ; Cytotoxicity ; Disease-Free Survival ; Female ; Flow cytometry ; Follow-Up Studies ; Health aspects ; Hematopoietic stem cells ; Humans ; Immune reconstitution ; Leukemia ; Lymphocyte Count ; Lymphocytes ; Lymphocytes T ; Male ; Medical sciences ; Natural killer cells ; Peripheral blood ; Peripheral Blood Stem Cell Transplantation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Prospective Studies ; Recovery of Function - immunology ; Risk factors ; Stem cell transplantation ; Stem cells ; Subgroups ; Survival ; Survival Rate ; T cells ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation, Homologous</subject><ispartof>Bone marrow transplantation (Basingstoke), 2007-03, Vol.39 (5), p.269-278</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2007</rights><rights>Nature Publishing Group 2007.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-739347cd35c69dcc8f2cd1a98fbb989aebc28c89c1151229db22070733d754753</citedby><cites>FETCH-LOGICAL-c468t-739347cd35c69dcc8f2cd1a98fbb989aebc28c89c1151229db22070733d754753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18565937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17311085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOEHL, U</creatorcontrib><creatorcontrib>BOCHENNEK, K</creatorcontrib><creatorcontrib>ORTH, A</creatorcontrib><creatorcontrib>BADER, P</creatorcontrib><creatorcontrib>SCHWABE, D</creatorcontrib><creatorcontrib>KLINGEBIEL, T</creatorcontrib><creatorcontrib>ZIMMERMANN, S. Y</creatorcontrib><creatorcontrib>LEHRNBECHER, T</creatorcontrib><creatorcontrib>SÖRENSEN, J</creatorcontrib><creatorcontrib>ESSER, R</creatorcontrib><creatorcontrib>ANDREAS, C</creatorcontrib><creatorcontrib>KRAMM, C</creatorcontrib><creatorcontrib>GRÜTTNER, H. P</creatorcontrib><creatorcontrib>FALKENBERG, E</creatorcontrib><title>Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8 CD3 count reconstitution is associated with survival</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>To evaluate the correlation between kinetics of immune reconstitution and survival, we prospectively evaluated lymphocyte subsets in 32 paediatric patients undergoing allogeneic stem cell transplantation (SCT) for haematological malignancies. Four-colour flow cytometric analysis was performed at short intervals with a median follow-up of 4 years post SCT. A total of 50% of patients reached age-matched 5th percentile of natural killer, cytotoxic T, B and helper T cells 4, 9, 20 and 28 weeks after SCT, respectively, which increased to more than 80% within 1 year after SCT. Transplantation of peripheral blood stem cells (PBSC) seemed to elicit the fastest reconstitution of CD3+, CD4+ CD3+, CD8+ CD3+ and naïve T cells compared to bone marrow (BM) or CD34-selected PBSC, which did not differ. Most importantly, we observed a significantly higher number of survivors among patients whose CD8+ CD3+ absolute counts rose above the 5th percentile of age-matched normal levels during the first year post SCT compared to patients who never reached these levels (19/25 vs 0/7, P<0.001). This was still present in both subgroups, BM- and CD34-selected grafts (P=0.03, 0.02). These results from a small patient sample underline the importance of particular lymphocyte subsets for the outcome of children undergoing SCT. A larger study with detailed subset analysis is underway.</description><subject>Adolescent</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Care and treatment</subject><subject>CD3 antigen</subject><subject>CD3 Complex - immunology</subject><subject>CD34 antigen</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>CD8 antigen</subject><subject>CD8 Antigens - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cytotoxicity</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Follow-Up Studies</subject><subject>Health aspects</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Immune reconstitution</subject><subject>Leukemia</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Natural killer cells</subject><subject>Peripheral blood</subject><subject>Peripheral Blood Stem Cell Transplantation</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Prospective Studies</subject><subject>Recovery of Function - immunology</subject><subject>Risk factors</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Subgroups</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>T cells</subject><subject>Transfusions. 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Graft versus host reaction</topic><topic>Care and treatment</topic><topic>CD3 antigen</topic><topic>CD3 Complex - immunology</topic><topic>CD34 antigen</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes</topic><topic>CD8 antigen</topic><topic>CD8 Antigens - immunology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cytotoxicity</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Follow-Up Studies</topic><topic>Health aspects</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Immune reconstitution</topic><topic>Leukemia</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Natural killer cells</topic><topic>Peripheral blood</topic><topic>Peripheral Blood Stem Cell Transplantation</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Prospective Studies</topic><topic>Recovery of Function - immunology</topic><topic>Risk factors</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Subgroups</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>T cells</topic><topic>Transfusions. 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| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2007-03, Vol.39 (5), p.269-278 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69032324 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone Marrow Cells Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment CD3 antigen CD3 Complex - immunology CD34 antigen CD4 antigen CD4-Positive T-Lymphocytes CD8 antigen CD8 Antigens - immunology CD8-Positive T-Lymphocytes - immunology Child Child, Preschool Children Cytotoxicity Disease-Free Survival Female Flow cytometry Follow-Up Studies Health aspects Hematopoietic stem cells Humans Immune reconstitution Leukemia Lymphocyte Count Lymphocytes Lymphocytes T Male Medical sciences Natural killer cells Peripheral blood Peripheral Blood Stem Cell Transplantation Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prospective Studies Recovery of Function - immunology Risk factors Stem cell transplantation Stem cells Subgroups Survival Survival Rate T cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Homologous |
| title | Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8 CD3 count reconstitution is associated with survival |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T02%3A56%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immune%20recovery%20in%20children%20undergoing%20allogeneic%20stem%20cell%20transplantation:%20absolute%20CD8%20CD3%20count%20reconstitution%20is%20associated%20with%20survival&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=KOEHL,%20U&rft.date=2007-03-01&rft.volume=39&rft.issue=5&rft.spage=269&rft.epage=278&rft.pages=269-278&rft.issn=0268-3369&rft.eissn=1476-5365&rft.coden=BMTRE9&rft_id=info:doi/10.1038/sj.bmt.1705584&rft_dat=%3Cgale_proqu%3EA182129509%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=216660260&rft_id=info:pmid/17311085&rft_galeid=A182129509&rfr_iscdi=true |