Meta‐analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy
Summary Background Despite numerous guidelines recommending prophylactic antibiotics prior to percutaneous endoscopic gastrostomy, their use remains controversial. Aim To conduct a systematic literature review and performed meta‐analyses to determine the benefit of antibiotic prophylaxis for percuta...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2007-03, Vol.25 (6), p.647-656 |
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| container_title | Alimentary pharmacology & therapeutics |
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| creator | JAFRI, N. S. MAHID, S. S. MINOR, K. S. IDSTEIN, S. R. HORNUNG, C. A. GALANDIUK, S. |
| description | Summary
Background
Despite numerous guidelines recommending prophylactic antibiotics prior to percutaneous endoscopic gastrostomy, their use remains controversial.
Aim
To conduct a systematic literature review and performed meta‐analyses to determine the benefit of antibiotic prophylaxis for percutaneous endoscopic gastrostomy placement.
Methods
We performed a systematic literature review by searching healthcare databases and grey literature for randomized‐controlled trials of antibiotic prophylaxis against wound infection after percutaneous endoscopic gastrostomy. Relative risks were calculated for individual trials and data pooled using fixed‐effects model. Relative risk reduction, absolute risk reduction and number needed to treat were calculated and are reported with 95% confidence intervals.
Results
Ten randomized‐controlled trials met the inclusion criteria and 1059 cases were pooled. Overall findings indicated that antibiotic prophylaxis resulted in a relative risk reduction of 64% and an absolute risk reduction of 15%. Number needed to treat to prevent one wound infection was 8. Cephalosporin prophylaxis was associated with a relative risk reduction of 64%, absolute risk reduction of 10% and number needed to treat of 10, whereas penicillin‐based prophylaxis was associated with a relative risk reduction of 62%, absolute risk reduction of 13% and number needed to treat of 8.
Conclusions
Antibiotic prophylaxis prior to percutaneous endoscopic gastrostomy is effective in reducing the incidence of percutaneous endoscopic gastrostomy site wound infection. Based on sensitivity analyses, penicillin‐based prophylaxis should be the prophylaxis of choice. |
| doi_str_mv | 10.1111/j.1365-2036.2007.03247.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69032320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69032320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5137-9dd71c73042dc18a51dc825d1ee925982b40d43d6bcff047b45f702b961dfb63</originalsourceid><addsrcrecordid>eNqNkM1u1DAUhS0EosPAK6BsYJfgn9hOkFhUFRSkIljM3nL8Uzzy2CF22smOR-AZeZI6zIhu8ca27jn3nvsBUCHYoHLe7RtEGK0xJKzBEPIGEtzy5vgEbP4VnoINxKyvcYfIBXiR0h5CyDjEz8EF4gQh2vMNmL-aLP_8-i2D9Ety6X0lQ3aDi9mpapzi-GPx8uhSlWP5mjsTcjWayaUcD9JXLlijsouhstH7eO_C7VpWc5bBxDlVJuiYVBxLt1uZ8hRX4_ISPLPSJ_PqfG_B7tPH3dXn-ubb9Zery5taUUR43WvNkeIEtlgr1EmKtOow1ciYHtO-w0MLdUs0G5S1sOVDS21ZcOgZ0nZgZAventqWRX7OJmVxcEkZ70_hBOsLN1JgbUF3EqoSME3GinFyBzktAkGxEhd7sYIVK1ixEhd_iYtjsb4-z5iHg9GPxjPiInhzFsikpLeTDMqlR11HKYGsLboPJ92982b57wDi8vtufZEH5kegyw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69032320</pqid></control><display><type>article</type><title>Meta‐analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>JAFRI, N. S. ; MAHID, S. S. ; MINOR, K. S. ; IDSTEIN, S. R. ; HORNUNG, C. A. ; GALANDIUK, S.</creator><creatorcontrib>JAFRI, N. S. ; MAHID, S. S. ; MINOR, K. S. ; IDSTEIN, S. R. ; HORNUNG, C. A. ; GALANDIUK, S.</creatorcontrib><description>Summary
Background
Despite numerous guidelines recommending prophylactic antibiotics prior to percutaneous endoscopic gastrostomy, their use remains controversial.
Aim
To conduct a systematic literature review and performed meta‐analyses to determine the benefit of antibiotic prophylaxis for percutaneous endoscopic gastrostomy placement.
Methods
We performed a systematic literature review by searching healthcare databases and grey literature for randomized‐controlled trials of antibiotic prophylaxis against wound infection after percutaneous endoscopic gastrostomy. Relative risks were calculated for individual trials and data pooled using fixed‐effects model. Relative risk reduction, absolute risk reduction and number needed to treat were calculated and are reported with 95% confidence intervals.
Results
Ten randomized‐controlled trials met the inclusion criteria and 1059 cases were pooled. Overall findings indicated that antibiotic prophylaxis resulted in a relative risk reduction of 64% and an absolute risk reduction of 15%. Number needed to treat to prevent one wound infection was 8. Cephalosporin prophylaxis was associated with a relative risk reduction of 64%, absolute risk reduction of 10% and number needed to treat of 10, whereas penicillin‐based prophylaxis was associated with a relative risk reduction of 62%, absolute risk reduction of 13% and number needed to treat of 8.
Conclusions
Antibiotic prophylaxis prior to percutaneous endoscopic gastrostomy is effective in reducing the incidence of percutaneous endoscopic gastrostomy site wound infection. Based on sensitivity analyses, penicillin‐based prophylaxis should be the prophylaxis of choice.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2007.03247.x</identifier><identifier>PMID: 17311597</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Antibiotic Prophylaxis - methods ; Biological and medical sciences ; Cephalosporins - therapeutic use ; Digestive system ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrostomy - methods ; Humans ; Medical sciences ; Penicillins - therapeutic use ; Pharmacology. Drug treatments ; Surgical Wound Infection - prevention & control</subject><ispartof>Alimentary pharmacology & therapeutics, 2007-03, Vol.25 (6), p.647-656</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5137-9dd71c73042dc18a51dc825d1ee925982b40d43d6bcff047b45f702b961dfb63</citedby><cites>FETCH-LOGICAL-c5137-9dd71c73042dc18a51dc825d1ee925982b40d43d6bcff047b45f702b961dfb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2007.03247.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2007.03247.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18553064$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17311597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JAFRI, N. S.</creatorcontrib><creatorcontrib>MAHID, S. S.</creatorcontrib><creatorcontrib>MINOR, K. S.</creatorcontrib><creatorcontrib>IDSTEIN, S. R.</creatorcontrib><creatorcontrib>HORNUNG, C. A.</creatorcontrib><creatorcontrib>GALANDIUK, S.</creatorcontrib><title>Meta‐analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Despite numerous guidelines recommending prophylactic antibiotics prior to percutaneous endoscopic gastrostomy, their use remains controversial.
Aim
To conduct a systematic literature review and performed meta‐analyses to determine the benefit of antibiotic prophylaxis for percutaneous endoscopic gastrostomy placement.
Methods
We performed a systematic literature review by searching healthcare databases and grey literature for randomized‐controlled trials of antibiotic prophylaxis against wound infection after percutaneous endoscopic gastrostomy. Relative risks were calculated for individual trials and data pooled using fixed‐effects model. Relative risk reduction, absolute risk reduction and number needed to treat were calculated and are reported with 95% confidence intervals.
Results
Ten randomized‐controlled trials met the inclusion criteria and 1059 cases were pooled. Overall findings indicated that antibiotic prophylaxis resulted in a relative risk reduction of 64% and an absolute risk reduction of 15%. Number needed to treat to prevent one wound infection was 8. Cephalosporin prophylaxis was associated with a relative risk reduction of 64%, absolute risk reduction of 10% and number needed to treat of 10, whereas penicillin‐based prophylaxis was associated with a relative risk reduction of 62%, absolute risk reduction of 13% and number needed to treat of 8.
Conclusions
Antibiotic prophylaxis prior to percutaneous endoscopic gastrostomy is effective in reducing the incidence of percutaneous endoscopic gastrostomy site wound infection. Based on sensitivity analyses, penicillin‐based prophylaxis should be the prophylaxis of choice.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotic Prophylaxis - methods</subject><subject>Biological and medical sciences</subject><subject>Cephalosporins - therapeutic use</subject><subject>Digestive system</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrostomy - methods</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Penicillins - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Surgical Wound Infection - prevention & control</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAUhS0EosPAK6BsYJfgn9hOkFhUFRSkIljM3nL8Uzzy2CF22smOR-AZeZI6zIhu8ca27jn3nvsBUCHYoHLe7RtEGK0xJKzBEPIGEtzy5vgEbP4VnoINxKyvcYfIBXiR0h5CyDjEz8EF4gQh2vMNmL-aLP_8-i2D9Ety6X0lQ3aDi9mpapzi-GPx8uhSlWP5mjsTcjWayaUcD9JXLlijsouhstH7eO_C7VpWc5bBxDlVJuiYVBxLt1uZ8hRX4_ISPLPSJ_PqfG_B7tPH3dXn-ubb9Zery5taUUR43WvNkeIEtlgr1EmKtOow1ciYHtO-w0MLdUs0G5S1sOVDS21ZcOgZ0nZgZAventqWRX7OJmVxcEkZ70_hBOsLN1JgbUF3EqoSME3GinFyBzktAkGxEhd7sYIVK1ixEhd_iYtjsb4-z5iHg9GPxjPiInhzFsikpLeTDMqlR11HKYGsLboPJ92982b57wDi8vtufZEH5kegyw</recordid><startdate>20070315</startdate><enddate>20070315</enddate><creator>JAFRI, N. S.</creator><creator>MAHID, S. S.</creator><creator>MINOR, K. S.</creator><creator>IDSTEIN, S. R.</creator><creator>HORNUNG, C. A.</creator><creator>GALANDIUK, S.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070315</creationdate><title>Meta‐analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy</title><author>JAFRI, N. S. ; MAHID, S. S. ; MINOR, K. S. ; IDSTEIN, S. R. ; HORNUNG, C. A. ; GALANDIUK, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5137-9dd71c73042dc18a51dc825d1ee925982b40d43d6bcff047b45f702b961dfb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotic Prophylaxis - methods</topic><topic>Biological and medical sciences</topic><topic>Cephalosporins - therapeutic use</topic><topic>Digestive system</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrostomy - methods</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Penicillins - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Surgical Wound Infection - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JAFRI, N. S.</creatorcontrib><creatorcontrib>MAHID, S. S.</creatorcontrib><creatorcontrib>MINOR, K. S.</creatorcontrib><creatorcontrib>IDSTEIN, S. R.</creatorcontrib><creatorcontrib>HORNUNG, C. A.</creatorcontrib><creatorcontrib>GALANDIUK, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JAFRI, N. S.</au><au>MAHID, S. S.</au><au>MINOR, K. S.</au><au>IDSTEIN, S. R.</au><au>HORNUNG, C. A.</au><au>GALANDIUK, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta‐analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2007-03-15</date><risdate>2007</risdate><volume>25</volume><issue>6</issue><spage>647</spage><epage>656</epage><pages>647-656</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Despite numerous guidelines recommending prophylactic antibiotics prior to percutaneous endoscopic gastrostomy, their use remains controversial.
Aim
To conduct a systematic literature review and performed meta‐analyses to determine the benefit of antibiotic prophylaxis for percutaneous endoscopic gastrostomy placement.
Methods
We performed a systematic literature review by searching healthcare databases and grey literature for randomized‐controlled trials of antibiotic prophylaxis against wound infection after percutaneous endoscopic gastrostomy. Relative risks were calculated for individual trials and data pooled using fixed‐effects model. Relative risk reduction, absolute risk reduction and number needed to treat were calculated and are reported with 95% confidence intervals.
Results
Ten randomized‐controlled trials met the inclusion criteria and 1059 cases were pooled. Overall findings indicated that antibiotic prophylaxis resulted in a relative risk reduction of 64% and an absolute risk reduction of 15%. Number needed to treat to prevent one wound infection was 8. Cephalosporin prophylaxis was associated with a relative risk reduction of 64%, absolute risk reduction of 10% and number needed to treat of 10, whereas penicillin‐based prophylaxis was associated with a relative risk reduction of 62%, absolute risk reduction of 13% and number needed to treat of 8.
Conclusions
Antibiotic prophylaxis prior to percutaneous endoscopic gastrostomy is effective in reducing the incidence of percutaneous endoscopic gastrostomy site wound infection. Based on sensitivity analyses, penicillin‐based prophylaxis should be the prophylaxis of choice.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17311597</pmid><doi>10.1111/j.1365-2036.2007.03247.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis - methods Biological and medical sciences Cephalosporins - therapeutic use Digestive system Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Gastrostomy - methods Humans Medical sciences Penicillins - therapeutic use Pharmacology. Drug treatments Surgical Wound Infection - prevention & control |
| title | Meta‐analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy |
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