Cdc42 Deficiency Causes Sonic Hedgehog-Independent Holoprosencephaly

The telencephalic neuroepithelium (NE) of mammalian brain has an apical-basal polarity that is marked by the positioning of neural progenitors and adherens junctions on the apical/ventricular surface and the ascending of radial glia/progenitor fibers toward the pial/basal surface. The signaling path...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-10, Vol.103 (44), p.16520-16525
Hauptverfasser:	Chen, Lei, Liao, Guanghong, Yang, Linda, Campbell, Kenneth, Nakafuku, Masato, Kuan, Chia-Yi, Zheng, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens junctions Animals Biological Sciences Bone Morphogenetic Proteins - metabolism cdc42 GTP-Binding Protein - deficiency cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell Polarity Cells Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryo, Mammalian - pathology Embryos Forebrain Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Genes Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Holoprosencephaly Holoprosencephaly - embryology Holoprosencephaly - genetics Holoprosencephaly - metabolism Holoprosencephaly - pathology Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Pathology Progenitor cells Proteins Rabbits Rodents Signal Transduction Stem cells Telencephalon
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