ZAP-70 enhances B-cell–receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells

Expression of ZAP-70 is an important negative prognostic factor in chronic lymphocytic leukemia (CLL). This protein tyrosine kinase is a key mediator of T-cell receptor (TCR) signaling and is structurally homologous to Syk, which plays an analogous role in B-cell receptor (BCR) signaling. Recent stu...

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Veröffentlicht in:	Blood 2007-03, Vol.109 (5), p.2032-2039
Hauptverfasser:	Gobessi, Stefania, Laurenti, Luca, Longo, Pablo G., Sica, Simona, Leone, Giuseppe, Efremov, Dimitar G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Biological and medical sciences Enzyme Activation Hematologic and hematopoietic diseases Humans Leukemia, B-Cell - genetics Leukemia, B-Cell - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Ligands Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism Medical sciences Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphotyrosine - metabolism Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-cbl - metabolism Receptors, Antigen, B-Cell - metabolism Shc Signaling Adaptor Proteins Signal Transduction Src Homology 2 Domain-Containing, Transforming Protein 1 Tumor Cells, Cultured ZAP-70 Protein-Tyrosine Kinase - genetics ZAP-70 Protein-Tyrosine Kinase - metabolism
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