PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs

Messenger RNAs produced by splicing are translated more efficiently than those produced from similar intronless precursor mRNAs (pre-mRNAs). The exon-junction complex (EJC) probably mediates this enhancement; however, the specific link between the EJC and the translation machinery has not been ident...

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Veröffentlicht in:	Nature structural & molecular biology 2007-12, Vol.14 (12), p.1173-1179
Hauptverfasser:	Diem, Michael D, Chan, Chia C, Younis, Ihab, Dreyfuss, Gideon
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Microscopy Biomedical and Life Sciences Carrier Proteins - metabolism Cell Line Cytoplasm - metabolism Exons Genetic engineering Humans Immunoprecipitation Life Sciences Membrane Biology Messenger RNA Molecular biology Physiological aspects Protein Binding Protein Biosynthesis Protein Structure Proteins Ribonucleic acid Ribosomes - metabolism RNA RNA Splicing RNA, Messenger - genetics Structure
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