Poly(ADP-ribose) makes a date with death
Poly(ADP-ribose) polymerase (PARP) enzymes catalyze the conversion of NAD + to polymers of poly(ADP-ribose) (PAR). Although its role in the DNA-damage response has long been recognized, recent work indicates that PAR itself acts at the mitochondria to directly induce cell death through stimulation o...
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| Veröffentlicht in: | Current opinion in chemical biology 2007-12, Vol.11 (6), p.644-653 |
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| container_title | Current opinion in chemical biology |
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| creator | Heeres, James T Hergenrother, Paul J |
| description | Poly(ADP-ribose) polymerase (PARP) enzymes catalyze the conversion of NAD
+ to polymers of poly(ADP-ribose) (PAR). Although its role in the DNA-damage response has long been recognized, recent work indicates that PAR itself acts at the mitochondria to directly induce cell death through stimulation of apoptosis-inducing factor (AIF) release. This review discusses PAR synthesis and degradation, and the role of PAR misregulation in various disease states. Attention is given to opportunities for therapeutic intervention with small molecules that are involved in PAR signaling, with specific focus on poly(ADP-ribose) glycohydrolase (PARG) and AIF. |
| doi_str_mv | 10.1016/j.cbpa.2007.08.038 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Apoptosis Inducing Factor - metabolism Cell Death - physiology Humans Poly Adenosine Diphosphate Ribose - metabolism Poly(ADP-ribose) Polymerases - metabolism Signal Transduction |
| title | Poly(ADP-ribose) makes a date with death |
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