Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics

This study aims to describe a population pharmacokinetic model for docetaxel in Asian breast cancer patients and to evaluate the effects of single-nucleotide polymorphisms (SNP) in the cytochrome P450 3A (CYP3A) gene expression regulators, constitutive androstane receptor (CAR), pregnane X receptor...

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Veröffentlicht in:	Clinical cancer research 2007-12, Vol.13 (23), p.7126-7132
Hauptverfasser:	Tham, Lai-San, Holford, Nicholas H G, Hor, Sok-Ying, Tan, Theresa, Wang, Lingzhi, Lim, Rui-Chen, Lee, How-Sung, Lee, Soo-Chin, Goh, Boon-Cher
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Female Gene Expression Regulation, Neoplastic Genotype Hepatocyte Nuclear Factor 4 - blood Hepatocyte Nuclear Factor 4 - genetics Hepatocyte Nuclear Factor 4 - metabolism Humans Middle Aged Polymorphism, Single Nucleotide Receptors, Cytoplasmic and Nuclear - genetics Receptors, Steroid - genetics Receptors, Steroid - metabolism Taxoids - administration & dosage Taxoids - pharmacokinetics Transcription Factors - genetics
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