Aurora-A Kinase Regulates Breast Cancer-Associated Gene 1 Inhibition of Centrosome-Dependent Microtubule Nucleation

Breast cancer-associated gene 1 (BRCA1) regulates the duplication and the function of centrosomes in breast cells. We have previously shown that BRCA1 ubiquitin ligase activity directly inhibits centrosome-dependent microtubule nucleation. However, there is a paradox because centrosome microtubule n...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-12, Vol.67 (23), p.11186-11194
Hauptverfasser:	SANKARAN, Satish, CRONE, Donna E, PALAZZO, Robert E, PARVIN, Jeffrey D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Aurora Kinases Biological and medical sciences BRCA1 Protein - antagonists & inhibitors BRCA1 Protein - genetics BRCA1 Protein - metabolism Cell Division - physiology Cell Nucleus - metabolism Centrosome - metabolism Gene Expression Regulation HeLa Cells - metabolism Humans Medical sciences Microtubules - metabolism Microtubules - ultrastructure Mitosis Mutation Pharmacology. Drug treatments Plasmids - metabolism Protein Phosphatase 1 - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Small Interfering - metabolism S Phase - physiology Tumor Suppressor Proteins - metabolism Tumors Ubiquitin - chemistry Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism Zinc Fingers
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