Xylarinic Acids A and B, New Antifungal Polypropionates from the Fruiting Body of Xylaria polymorpha
Two new polypropionates designated as xylarinic acids A and B were isolated from the fruiting body of Xylaria polymorpha . Their structures were established as 4,6,8-trimethyl-2,4-decadienoic acid and 2,4,6-trimethyl-2-octenoic acid, respectively, on the basis of extensive spectroscopic analysis. Bo...
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| Veröffentlicht in: | Journal of antibiotics 2007-11, Vol.60 (11), p.696-699 |
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| creator | Jang, Yun-Woo Lee, In-Kyoung Kim, Young-Sook Lee, Sangku Lee, Ho-Jae Yu, Seung Hun Yun, Bong-Sik |
| description | Two new polypropionates designated as xylarinic acids A and B were isolated from the fruiting body of
Xylaria polymorpha
. Their structures were established as 4,6,8-trimethyl-2,4-decadienoic acid and 2,4,6-trimethyl-2-octenoic acid, respectively, on the basis of extensive spectroscopic analysis. Both compounds displayed significant antifungal activity against plant pathogenic fungi
Pythium ultinum
,
Magnaporthe grisea
,
Aspergillus niger
,
Alternaria panax
, and
Fusarium oxysporium
, whereas they did not show antibacterial and cytotoxic effect. |
| doi_str_mv | 10.1038/ja.2007.89 |
| format | Article |
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Xylaria polymorpha
. Their structures were established as 4,6,8-trimethyl-2,4-decadienoic acid and 2,4,6-trimethyl-2-octenoic acid, respectively, on the basis of extensive spectroscopic analysis. Both compounds displayed significant antifungal activity against plant pathogenic fungi
Pythium ultinum
,
Magnaporthe grisea
,
Aspergillus niger
,
Alternaria panax
, and
Fusarium oxysporium
, whereas they did not show antibacterial and cytotoxic effect.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2007.89</identifier><identifier>PMID: 18057699</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alternaria ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Ascomycota - chemistry ; Aspergillus niger ; Bacteria - drug effects ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Cell Line, Tumor ; Chemical Phenomena ; Chemistry, Physical ; Drug Screening Assays, Antitumor ; Fatty Acids, Monounsaturated - isolation & purification ; Fatty Acids, Monounsaturated - pharmacology ; Fatty Acids, Unsaturated - isolation & purification ; Fatty Acids, Unsaturated - pharmacology ; Fruiting Bodies, Fungal - chemistry ; Fusarium ; Humans ; Life Sciences ; Magnaporthe grisea ; Magnetic Resonance Spectroscopy ; Medicinal Chemistry ; Microbial Sensitivity Tests ; Microbiology ; Organic Chemistry ; original-article ; Panax ; Pythium ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet ; Tetrazolium Salts ; Thiazoles</subject><ispartof>Journal of antibiotics, 2007-11, Vol.60 (11), p.696-699</ispartof><rights>Japan Antibiotics Research Association 2007</rights><rights>Copyright Nature Publishing Group Nov 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-48b0dea706e4118b2897dee0166d0ebc5391b1ac0db3f0d297d50ef682cbc0ee3</citedby><cites>FETCH-LOGICAL-c445t-48b0dea706e4118b2897dee0166d0ebc5391b1ac0db3f0d297d50ef682cbc0ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18057699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Yun-Woo</creatorcontrib><creatorcontrib>Lee, In-Kyoung</creatorcontrib><creatorcontrib>Kim, Young-Sook</creatorcontrib><creatorcontrib>Lee, Sangku</creatorcontrib><creatorcontrib>Lee, Ho-Jae</creatorcontrib><creatorcontrib>Yu, Seung Hun</creatorcontrib><creatorcontrib>Yun, Bong-Sik</creatorcontrib><title>Xylarinic Acids A and B, New Antifungal Polypropionates from the Fruiting Body of Xylaria polymorpha</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>Two new polypropionates designated as xylarinic acids A and B were isolated from the fruiting body of
Xylaria polymorpha
. Their structures were established as 4,6,8-trimethyl-2,4-decadienoic acid and 2,4,6-trimethyl-2-octenoic acid, respectively, on the basis of extensive spectroscopic analysis. Both compounds displayed significant antifungal activity against plant pathogenic fungi
Pythium ultinum
,
Magnaporthe grisea
,
Aspergillus niger
,
Alternaria panax
, and
Fusarium oxysporium
, whereas they did not show antibacterial and cytotoxic effect.</description><subject>Alternaria</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Ascomycota - chemistry</subject><subject>Aspergillus niger</subject><subject>Bacteria - drug effects</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Cell Line, Tumor</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Fatty Acids, Monounsaturated - isolation & purification</subject><subject>Fatty Acids, Monounsaturated - pharmacology</subject><subject>Fatty Acids, Unsaturated - isolation & purification</subject><subject>Fatty Acids, Unsaturated - pharmacology</subject><subject>Fruiting Bodies, Fungal - chemistry</subject><subject>Fusarium</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Magnaporthe grisea</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Panax</subject><subject>Pythium</subject><subject>Spectrophotometry, Infrared</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tetrazolium Salts</subject><subject>Thiazoles</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0U1rFDEYB_AgFrutXvwAEhA8aGd9knlJctyWVgtFPSh4C5nkme0sM8k0mUH225uyC4oeesrh-eWflz8hrxmsGZTy486sOYBYS_WMrJiUrGBVo56TFQBnhZQcTslZSjuAUpRCviCnTEItGqVWxP3cDyb2vrd0Y3uX6IYa7-jlBf2Cv-jGz323-K0Z6Lcw7KcYpj54M2OiXQwjne-R3sSln3u_pZfB7Wno6CHR0CnvGEOc7s1LctKZIeGr43pOftxcf7_6XNx9_XR7tbkrbFXVc1HJFhwaAQ1WjMmWSyUcIrCmcYCtrUvFWmYsuLbswPE8rQG7RnLbWkAsz8m7Q26-6MOCadZjnywOg_EYlqQbBVwKIZ-EHDjUjPEM3_4Dd2GJPj9CMyFF_kYlWFbvD8rGkFLETk-xH03cawb6sSK9M_qxIi1Vxm-OkUs7ovtDj51k8OEAUh75Lca_zvw_7jdBgZnZ</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Jang, Yun-Woo</creator><creator>Lee, In-Kyoung</creator><creator>Kim, Young-Sook</creator><creator>Lee, Sangku</creator><creator>Lee, Ho-Jae</creator><creator>Yu, Seung Hun</creator><creator>Yun, Bong-Sik</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Xylarinic Acids A and B, New Antifungal Polypropionates from the Fruiting Body of Xylaria polymorpha</title><author>Jang, Yun-Woo ; Lee, In-Kyoung ; Kim, Young-Sook ; Lee, Sangku ; Lee, Ho-Jae ; Yu, Seung Hun ; Yun, Bong-Sik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-48b0dea706e4118b2897dee0166d0ebc5391b1ac0db3f0d297d50ef682cbc0ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alternaria</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Ascomycota - chemistry</topic><topic>Aspergillus niger</topic><topic>Bacteria - drug effects</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Cell Line, Tumor</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Fatty Acids, Monounsaturated - isolation & purification</topic><topic>Fatty Acids, Monounsaturated - pharmacology</topic><topic>Fatty Acids, Unsaturated - isolation & purification</topic><topic>Fatty Acids, Unsaturated - pharmacology</topic><topic>Fruiting Bodies, Fungal - chemistry</topic><topic>Fusarium</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Magnaporthe grisea</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medicinal Chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Panax</topic><topic>Pythium</topic><topic>Spectrophotometry, Infrared</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tetrazolium Salts</topic><topic>Thiazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Yun-Woo</creatorcontrib><creatorcontrib>Lee, In-Kyoung</creatorcontrib><creatorcontrib>Kim, Young-Sook</creatorcontrib><creatorcontrib>Lee, Sangku</creatorcontrib><creatorcontrib>Lee, Ho-Jae</creatorcontrib><creatorcontrib>Yu, Seung Hun</creatorcontrib><creatorcontrib>Yun, Bong-Sik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Yun-Woo</au><au>Lee, In-Kyoung</au><au>Kim, Young-Sook</au><au>Lee, Sangku</au><au>Lee, Ho-Jae</au><au>Yu, Seung Hun</au><au>Yun, Bong-Sik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xylarinic Acids A and B, New Antifungal Polypropionates from the Fruiting Body of Xylaria polymorpha</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>60</volume><issue>11</issue><spage>696</spage><epage>699</epage><pages>696-699</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Two new polypropionates designated as xylarinic acids A and B were isolated from the fruiting body of
Xylaria polymorpha
. Their structures were established as 4,6,8-trimethyl-2,4-decadienoic acid and 2,4,6-trimethyl-2-octenoic acid, respectively, on the basis of extensive spectroscopic analysis. Both compounds displayed significant antifungal activity against plant pathogenic fungi
Pythium ultinum
,
Magnaporthe grisea
,
Aspergillus niger
,
Alternaria panax
, and
Fusarium oxysporium
, whereas they did not show antibacterial and cytotoxic effect.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18057699</pmid><doi>10.1038/ja.2007.89</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of antibiotics, 2007-11, Vol.60 (11), p.696-699 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alternaria Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Ascomycota - chemistry Aspergillus niger Bacteria - drug effects Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Chemical Phenomena Chemistry, Physical Drug Screening Assays, Antitumor Fatty Acids, Monounsaturated - isolation & purification Fatty Acids, Monounsaturated - pharmacology Fatty Acids, Unsaturated - isolation & purification Fatty Acids, Unsaturated - pharmacology Fruiting Bodies, Fungal - chemistry Fusarium Humans Life Sciences Magnaporthe grisea Magnetic Resonance Spectroscopy Medicinal Chemistry Microbial Sensitivity Tests Microbiology Organic Chemistry original-article Panax Pythium Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Tetrazolium Salts Thiazoles |
| title | Xylarinic Acids A and B, New Antifungal Polypropionates from the Fruiting Body of Xylaria polymorpha |
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