A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis

Fusion of vesicles into target membranes during many types of regulated exocytosis requires both SNARE-complex proteins and fusogenic lipids, such as phosphatidic acid. Mitochondrial fusion is less well understood but distinct, as it is mediated instead by the protein Mitofusin (Mfn). Here, we ident...

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Veröffentlicht in:	Nature cell biology 2006-11, Vol.8 (11), p.1255-1262
Hauptverfasser:	Frohman, Michael A, Choi, Seok-Yong, Huang, Ping, Jenkins, Gary M, Chan, David C, Schiller, Juergen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Biology Biomedical and Life Sciences Blotting, Western Cancer Research Cardiolipins - metabolism Cell Biology Developmental Biology Dimerization Enzymes Exocytosis Exocytosis - physiology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism GTP Phosphohydrolases - metabolism GTP Phosphohydrolases - physiology HeLa Cells Humans letter Life Sciences Lipids Localization Membrane fusion Membrane Fusion - physiology Membranes Mice Microscopy Microscopy, Confocal Microscopy, Electron Mitochondria Mitochondria - enzymology Mitochondria - metabolism Mitochondrial Membranes - physiology Mitochondrial Membranes - ultrastructure Mitochondrial Proteins - chemistry Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism NIH 3T3 Cells Phosphatidic Acids - metabolism Phospholipase D - chemistry Phospholipase D - genetics Phospholipase D - metabolism Physiological aspects Plasmids Proteins RNA Interference SNARE Proteins - physiology Stem Cells Transfection
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