Food groups and risk of hepatocellular carcinoma: A multicenter case‐control study in Italy
The role of diet, except for alcohol drinking and aflatoxin contamination, in the etiology of hepatocellular carcinoma (HCC) is unclear. A hospital‐based case‐control study was conducted in Italy in 1999–2002, including 185 incident, histologically‐confirmed cases of HCC. Controls were 412 subjects...
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| Veröffentlicht in: | International journal of cancer 2006-12, Vol.119 (12), p.2916-2921 |
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| container_title | International journal of cancer |
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| creator | Talamini, Renato Polesel, Jerry Montella, Maurizio Maso, Luigino Dal Crispo, Anna Tommasi, Luigi G. Izzo, Francesco Crovatto, Marina Vecchia, Carlo La Franceschi, Silvia |
| description | The role of diet, except for alcohol drinking and aflatoxin contamination, in the etiology of hepatocellular carcinoma (HCC) is unclear. A hospital‐based case‐control study was conducted in Italy in 1999–2002, including 185 incident, histologically‐confirmed cases of HCC. Controls were 412 subjects admitted to hospitals for acute, nonneoplastic diseases unrelated to diet. Dietary habits were assessed using a validated food‐frequency questionnaire. Odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis B (HBV) and hepatitis C (HCV) virus infection and alcohol drinking. Energy adjustment was carried out by means of the residual model. A significant inverse relation was found between intakes of milk and yoghurt (OR = 0.28; 95% CI: 0.13–0.61), white meats (OR = 0.44; 95% CI: 0.20–0.95), eggs (OR = 0.31; 95% CI: 0.14–0.69), and fruits (OR = 0.48; 95% CI: 0.22–1.05) and HCC risk. The favourable effect of high intakes of milk and yoghurt, white meats, eggs and fruits was consistent across strata of HBV and HCV infections. The present study supports the hypothesis of a role of diet in HCC aetiology. Dietary modifications may be indicated in subjects at high‐risk for HCC. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.22267 |
| format | Article |
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A hospital‐based case‐control study was conducted in Italy in 1999–2002, including 185 incident, histologically‐confirmed cases of HCC. Controls were 412 subjects admitted to hospitals for acute, nonneoplastic diseases unrelated to diet. Dietary habits were assessed using a validated food‐frequency questionnaire. Odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis B (HBV) and hepatitis C (HCV) virus infection and alcohol drinking. Energy adjustment was carried out by means of the residual model. A significant inverse relation was found between intakes of milk and yoghurt (OR = 0.28; 95% CI: 0.13–0.61), white meats (OR = 0.44; 95% CI: 0.20–0.95), eggs (OR = 0.31; 95% CI: 0.14–0.69), and fruits (OR = 0.48; 95% CI: 0.22–1.05) and HCC risk. The favourable effect of high intakes of milk and yoghurt, white meats, eggs and fruits was consistent across strata of HBV and HCV infections. The present study supports the hypothesis of a role of diet in HCC aetiology. Dietary modifications may be indicated in subjects at high‐risk for HCC. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.22267</identifier><identifier>PMID: 16998792</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Hepatocellular - epidemiology ; Case-Control Studies ; case‐control study ; Diet ; Feeding Behavior ; Female ; Food ; fruit ; Gastroenterology. Liver. Pancreas. Abdomen ; hepatocellular carcinoma ; Humans ; Incidence ; Italy - epidemiology ; Liver Neoplasms - epidemiology ; Liver. Biliary tract. Portal circulation. 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A hospital‐based case‐control study was conducted in Italy in 1999–2002, including 185 incident, histologically‐confirmed cases of HCC. Controls were 412 subjects admitted to hospitals for acute, nonneoplastic diseases unrelated to diet. Dietary habits were assessed using a validated food‐frequency questionnaire. Odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis B (HBV) and hepatitis C (HCV) virus infection and alcohol drinking. Energy adjustment was carried out by means of the residual model. A significant inverse relation was found between intakes of milk and yoghurt (OR = 0.28; 95% CI: 0.13–0.61), white meats (OR = 0.44; 95% CI: 0.20–0.95), eggs (OR = 0.31; 95% CI: 0.14–0.69), and fruits (OR = 0.48; 95% CI: 0.22–1.05) and HCC risk. The favourable effect of high intakes of milk and yoghurt, white meats, eggs and fruits was consistent across strata of HBV and HCV infections. The present study supports the hypothesis of a role of diet in HCC aetiology. Dietary modifications may be indicated in subjects at high‐risk for HCC. © 2006 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Case-Control Studies</subject><subject>case‐control study</subject><subject>Diet</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Food</subject><subject>fruit</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Incidence</subject><subject>Italy - epidemiology</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>milk</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9LwzAYBvAgipvTg19AclHwsC3_2qbexnA6GXjRo5Q0TTUzbWbSIrv5EfyMfhIzW9jJUyDvj_d9eAA4x2iCESJTvZYTQkicHIAhRmkyRgRHh2AYZmicYBoPwIn3a4QwjhA7BgMcpylPUjIELwtrC_jqbLvxUNQFdNq_Q1vCN7URjZXKmNYIB6VwUte2EjdwBqvWNFqqulG7gVc_X9_S1o2zBvqmLbZQ13DZCLM9BUelMF6d9e8IPC9un-b349Xj3XI-W40lwyGuJIKzmLMoRbLgkuaCRiRllBQiVwXPw5-MlOQIc4RYxCTOS1UqHimGacFTOgJX3d6Nsx-t8k1Wab_LLmplW5_FKSIJozTA6w5KZ713qsw2TlfCbTOMsl2XWegy--sy2It-aZtXqtjLvrwALnsgvBSmdKKW2u8dpygKmYObdu5TG7X9_2K2fJh3p38BS02MMw</recordid><startdate>20061215</startdate><enddate>20061215</enddate><creator>Talamini, Renato</creator><creator>Polesel, Jerry</creator><creator>Montella, Maurizio</creator><creator>Maso, Luigino Dal</creator><creator>Crispo, Anna</creator><creator>Tommasi, Luigi G.</creator><creator>Izzo, Francesco</creator><creator>Crovatto, Marina</creator><creator>Vecchia, Carlo La</creator><creator>Franceschi, Silvia</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061215</creationdate><title>Food groups and risk of hepatocellular carcinoma: A multicenter case‐control study in Italy</title><author>Talamini, Renato ; Polesel, Jerry ; Montella, Maurizio ; Maso, Luigino Dal ; Crispo, Anna ; Tommasi, Luigi G. ; Izzo, Francesco ; Crovatto, Marina ; Vecchia, Carlo La ; Franceschi, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4197-c2a84684590cd8c3ba3529432dabed8bd8cc5ec801800454c1bfefe85e413d893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Case-Control Studies</topic><topic>case‐control study</topic><topic>Diet</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Food</topic><topic>fruit</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Incidence</topic><topic>Italy - epidemiology</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>milk</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talamini, Renato</creatorcontrib><creatorcontrib>Polesel, Jerry</creatorcontrib><creatorcontrib>Montella, Maurizio</creatorcontrib><creatorcontrib>Maso, Luigino Dal</creatorcontrib><creatorcontrib>Crispo, Anna</creatorcontrib><creatorcontrib>Tommasi, Luigi G.</creatorcontrib><creatorcontrib>Izzo, Francesco</creatorcontrib><creatorcontrib>Crovatto, Marina</creatorcontrib><creatorcontrib>Vecchia, Carlo La</creatorcontrib><creatorcontrib>Franceschi, Silvia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talamini, Renato</au><au>Polesel, Jerry</au><au>Montella, Maurizio</au><au>Maso, Luigino Dal</au><au>Crispo, Anna</au><au>Tommasi, Luigi G.</au><au>Izzo, Francesco</au><au>Crovatto, Marina</au><au>Vecchia, Carlo La</au><au>Franceschi, Silvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Food groups and risk of hepatocellular carcinoma: A multicenter case‐control study in Italy</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2006-12-15</date><risdate>2006</risdate><volume>119</volume><issue>12</issue><spage>2916</spage><epage>2921</epage><pages>2916-2921</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>The role of diet, except for alcohol drinking and aflatoxin contamination, in the etiology of hepatocellular carcinoma (HCC) is unclear. A hospital‐based case‐control study was conducted in Italy in 1999–2002, including 185 incident, histologically‐confirmed cases of HCC. Controls were 412 subjects admitted to hospitals for acute, nonneoplastic diseases unrelated to diet. Dietary habits were assessed using a validated food‐frequency questionnaire. Odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis B (HBV) and hepatitis C (HCV) virus infection and alcohol drinking. Energy adjustment was carried out by means of the residual model. A significant inverse relation was found between intakes of milk and yoghurt (OR = 0.28; 95% CI: 0.13–0.61), white meats (OR = 0.44; 95% CI: 0.20–0.95), eggs (OR = 0.31; 95% CI: 0.14–0.69), and fruits (OR = 0.48; 95% CI: 0.22–1.05) and HCC risk. The favourable effect of high intakes of milk and yoghurt, white meats, eggs and fruits was consistent across strata of HBV and HCV infections. The present study supports the hypothesis of a role of diet in HCC aetiology. Dietary modifications may be indicated in subjects at high‐risk for HCC. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16998792</pmid><doi>10.1002/ijc.22267</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Hepatocellular - epidemiology Case-Control Studies case‐control study Diet Feeding Behavior Female Food fruit Gastroenterology. Liver. Pancreas. Abdomen hepatocellular carcinoma Humans Incidence Italy - epidemiology Liver Neoplasms - epidemiology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged milk Odds Ratio Risk Factors Surveys and Questionnaires Tumors |
| title | Food groups and risk of hepatocellular carcinoma: A multicenter case‐control study in Italy |
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