Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling

Extracellular high-mobility group box 1 protein (HMGB1) triggers inflammatory events in the brain. We demonstrate that astrocytes, the main glial cells in the brain, acquire a specific reactive phenotype when exposed to HMGB1. This cell activation, which involves the receptor for advanced glycation...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-12, Vol.179 (12), p.8525-8532
Hauptverfasser:	Pedrazzi, Marco, Patrone, Mauro, Passalacqua, Mario, Ranzato, Elia, Colamassaro, Diego, Sparatore, Bianca, Pontremoli, Sandro, Melloni, Edon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - immunology Cells, Cultured Chemokines - analysis Chemokines - genetics Chemokines - metabolism Encephalitis - genetics Encephalitis - immunology Gene Expression - drug effects HMGB1 Protein - metabolism HMGB1 Protein - pharmacology Leukocytes - metabolism Metalloproteases - analysis Metalloproteases - genetics Metalloproteases - metabolism Proteomics Rats Recombinant Proteins - pharmacology Signal Transduction
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