Agonists of Toll-like Receptor 9 Containing Synthetic Dinucleotide Motifs

Oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs activate Toll-like receptor 9 (TLR9). Our previous studies have shown that ODNs containing two 5′-ends are more immunostimulatory than those with one 5′-end. In the present study, to understand the role of functional groups in TLR9 reco...

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