MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility
Objectives. Several recent studies have shown that the MHC class III region, located telomeric to HLA-DRB1, contains an additional genetic factor that predisposes to rheumatoid arthritis (RA). In this study, we investigate whether inhibitor of κB-like (IκBL), MICB or MICA located in the MHC class II...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2007-03, Vol.46 (3), p.426-430 |
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| creator | López-Arbesu, R. Ballina-García, F. J. Alperi-López, M. López-Soto, A. Rodríguez-Rodero, S. Martínez-Borra, J. López-Vázquez, A. Fernández-Morera, J. L. Riestra-Noriega, J. L. Queiro-Silva, R. Quiñones-Lombraña, A. López-Larrea, C. González, S. |
| description | Objectives. Several recent studies have shown that the MHC class III region, located telomeric to HLA-DRB1, contains an additional genetic factor that predisposes to rheumatoid arthritis (RA). In this study, we investigate whether inhibitor of κB-like (IκBL), MICB or MICA located in the MHC class III region are the second susceptibility gene associated with RA.
Methods. A total of 154 healthy controls and 140 RA patients were genotyped for HLA-DRB1, MICA, MICB and the polymorphism −62 of the IκBL gene.
Results. A significant increase of HLA-DRB1 shared epitope (SE) alleles was detected in RA patients (61.4 vs 43.5%, Pc
= 0.01, OR = 2.1, 95% CI = 1.3-3.3). Among SE alleles, the HLA-DRB1*0401 (13.5 vs 5.1%, Pc
= 0.04, OR = 3.2, 95% CI = 1.3-8.1) and HLA-DRB1*0404 (6.4 vs 1.2%, P = 0.02, Pc
= NS) showed the most significantly association with RA. No increase of risk was associated with HLA-DRB1*01. Remarkably, the allele MICB*004 was also significantly associated with RA susceptibility (40.7 vs 23.3%, Pc
= 0.01, OR = 2.2, 95% CI = 1.3-3.7). MICB*004 was in linkage disequilibrium with HLA-DRB1*0404 (λs = 0.33) and HLA-DRB1*0405 (λs = 0.34). However, MICB*004 was also increased in HLA-DRB1 SE negative patients (37 vs 21.5%, P = 0.04). No significant association between IκBL and MICA with RA was found.
Conclusions. MICB*004 allele was associated with RA susceptibility. This allele was in linkage disequilibrium with HLA-DRB1*0404 and DRB1*0405. The association of MICB with RA susceptibility and the functional role of MIC genes in the pathogenesis of RA converts MICB into a candidate to be an additional MHC gene associated with RA susceptibility. |
| doi_str_mv | 10.1093/rheumatology/kel331 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69025030</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/rheumatology/kel331</oup_id><sourcerecordid>19840988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-3259e79ccc79ad8ef1362163ef8f282cb65082ceba591740a6a5f06b7349698d3</originalsourceid><addsrcrecordid>eNqN0ctKJDEUBuAgDt6fQJAgjDiL0lwqt6U2ajfYuJnZWqRSKTuarmqTFEO_vZnp9oIbXZ1AvnNywg_AIUZnGCl6HmZ2mOvU-_5hef5kPaV4A-zgkpMCUUo2386k3Aa7MT4ihBimcgtsY4EQxYLvgPvpeASN1zHCCTQz7boiWK-TbeCD7Sy8hKfTyejyF3QRZtQb9__ur0sz-LqAa6AOaRZcyigO0dhFcrXzLi33wY9W-2gP1nUP_Lm--j0aF7d3N5PRxW1hSsFSQQlTVihjjFC6kbbFlBPMqW1lSyQxNWcoF1trprAokeaatYjXgpaKK9nQPXCymrsI_fNgY6rmLu_hve5sP8SKK0QYouhLiJUskZIyw-NP8LEfQpc_kQ3jXFBeZkRXyIQ-xmDbahHcXIdlhVH1L6TqY0jVKqTcdbQePdRz27z3rFPJ4Oca6Gi0b4PujIvvTjKlGBHZna1cPyy-9fILCb-t_w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195667364</pqid></control><display><type>article</type><title>MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>López-Arbesu, R. ; Ballina-García, F. J. ; Alperi-López, M. ; López-Soto, A. ; Rodríguez-Rodero, S. ; Martínez-Borra, J. ; López-Vázquez, A. ; Fernández-Morera, J. L. ; Riestra-Noriega, J. L. ; Queiro-Silva, R. ; Quiñones-Lombraña, A. ; López-Larrea, C. ; González, S.</creator><creatorcontrib>López-Arbesu, R. ; Ballina-García, F. J. ; Alperi-López, M. ; López-Soto, A. ; Rodríguez-Rodero, S. ; Martínez-Borra, J. ; López-Vázquez, A. ; Fernández-Morera, J. L. ; Riestra-Noriega, J. L. ; Queiro-Silva, R. ; Quiñones-Lombraña, A. ; López-Larrea, C. ; González, S.</creatorcontrib><description>Objectives. Several recent studies have shown that the MHC class III region, located telomeric to HLA-DRB1, contains an additional genetic factor that predisposes to rheumatoid arthritis (RA). In this study, we investigate whether inhibitor of κB-like (IκBL), MICB or MICA located in the MHC class III region are the second susceptibility gene associated with RA.
Methods. A total of 154 healthy controls and 140 RA patients were genotyped for HLA-DRB1, MICA, MICB and the polymorphism −62 of the IκBL gene.
Results. A significant increase of HLA-DRB1 shared epitope (SE) alleles was detected in RA patients (61.4 vs 43.5%, Pc
= 0.01, OR = 2.1, 95% CI = 1.3-3.3). Among SE alleles, the HLA-DRB1*0401 (13.5 vs 5.1%, Pc
= 0.04, OR = 3.2, 95% CI = 1.3-8.1) and HLA-DRB1*0404 (6.4 vs 1.2%, P = 0.02, Pc
= NS) showed the most significantly association with RA. No increase of risk was associated with HLA-DRB1*01. Remarkably, the allele MICB*004 was also significantly associated with RA susceptibility (40.7 vs 23.3%, Pc
= 0.01, OR = 2.2, 95% CI = 1.3-3.7). MICB*004 was in linkage disequilibrium with HLA-DRB1*0404 (λs = 0.33) and HLA-DRB1*0405 (λs = 0.34). However, MICB*004 was also increased in HLA-DRB1 SE negative patients (37 vs 21.5%, P = 0.04). No significant association between IκBL and MICA with RA was found.
Conclusions. MICB*004 allele was associated with RA susceptibility. This allele was in linkage disequilibrium with HLA-DRB1*0404 and DRB1*0405. The association of MICB with RA susceptibility and the functional role of MIC genes in the pathogenesis of RA converts MICB into a candidate to be an additional MHC gene associated with RA susceptibility.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/kel331</identifier><identifier>PMID: 17003176</identifier><identifier>CODEN: BJRHDF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid - genetics ; Biological and medical sciences ; Diseases of the osteoarticular system ; Female ; Genetic Predisposition to Disease ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class II - genetics ; Histocompatibility Testing - methods ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Inflammatory joint diseases ; Linkage Disequilibrium ; Male ; Medical sciences ; Middle Aged</subject><ispartof>Rheumatology (Oxford, England), 2007-03, Vol.46 (3), p.426-430</ispartof><rights>The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2006</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Mar 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-3259e79ccc79ad8ef1362163ef8f282cb65082ceba591740a6a5f06b7349698d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18599527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17003176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Arbesu, R.</creatorcontrib><creatorcontrib>Ballina-García, F. J.</creatorcontrib><creatorcontrib>Alperi-López, M.</creatorcontrib><creatorcontrib>López-Soto, A.</creatorcontrib><creatorcontrib>Rodríguez-Rodero, S.</creatorcontrib><creatorcontrib>Martínez-Borra, J.</creatorcontrib><creatorcontrib>López-Vázquez, A.</creatorcontrib><creatorcontrib>Fernández-Morera, J. L.</creatorcontrib><creatorcontrib>Riestra-Noriega, J. L.</creatorcontrib><creatorcontrib>Queiro-Silva, R.</creatorcontrib><creatorcontrib>Quiñones-Lombraña, A.</creatorcontrib><creatorcontrib>López-Larrea, C.</creatorcontrib><creatorcontrib>González, S.</creatorcontrib><title>MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Objectives. Several recent studies have shown that the MHC class III region, located telomeric to HLA-DRB1, contains an additional genetic factor that predisposes to rheumatoid arthritis (RA). In this study, we investigate whether inhibitor of κB-like (IκBL), MICB or MICA located in the MHC class III region are the second susceptibility gene associated with RA.
Methods. A total of 154 healthy controls and 140 RA patients were genotyped for HLA-DRB1, MICA, MICB and the polymorphism −62 of the IκBL gene.
Results. A significant increase of HLA-DRB1 shared epitope (SE) alleles was detected in RA patients (61.4 vs 43.5%, Pc
= 0.01, OR = 2.1, 95% CI = 1.3-3.3). Among SE alleles, the HLA-DRB1*0401 (13.5 vs 5.1%, Pc
= 0.04, OR = 3.2, 95% CI = 1.3-8.1) and HLA-DRB1*0404 (6.4 vs 1.2%, P = 0.02, Pc
= NS) showed the most significantly association with RA. No increase of risk was associated with HLA-DRB1*01. Remarkably, the allele MICB*004 was also significantly associated with RA susceptibility (40.7 vs 23.3%, Pc
= 0.01, OR = 2.2, 95% CI = 1.3-3.7). MICB*004 was in linkage disequilibrium with HLA-DRB1*0404 (λs = 0.33) and HLA-DRB1*0405 (λs = 0.34). However, MICB*004 was also increased in HLA-DRB1 SE negative patients (37 vs 21.5%, P = 0.04). No significant association between IκBL and MICA with RA was found.
Conclusions. MICB*004 allele was associated with RA susceptibility. This allele was in linkage disequilibrium with HLA-DRB1*0404 and DRB1*0405. The association of MICB with RA susceptibility and the functional role of MIC genes in the pathogenesis of RA converts MICB into a candidate to be an additional MHC gene associated with RA susceptibility.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Testing - methods</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctKJDEUBuAgDt6fQJAgjDiL0lwqt6U2ajfYuJnZWqRSKTuarmqTFEO_vZnp9oIbXZ1AvnNywg_AIUZnGCl6HmZ2mOvU-_5hef5kPaV4A-zgkpMCUUo2386k3Aa7MT4ihBimcgtsY4EQxYLvgPvpeASN1zHCCTQz7boiWK-TbeCD7Sy8hKfTyejyF3QRZtQb9__ur0sz-LqAa6AOaRZcyigO0dhFcrXzLi33wY9W-2gP1nUP_Lm--j0aF7d3N5PRxW1hSsFSQQlTVihjjFC6kbbFlBPMqW1lSyQxNWcoF1trprAokeaatYjXgpaKK9nQPXCymrsI_fNgY6rmLu_hve5sP8SKK0QYouhLiJUskZIyw-NP8LEfQpc_kQ3jXFBeZkRXyIQ-xmDbahHcXIdlhVH1L6TqY0jVKqTcdbQePdRz27z3rFPJ4Oca6Gi0b4PujIvvTjKlGBHZna1cPyy-9fILCb-t_w</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>López-Arbesu, R.</creator><creator>Ballina-García, F. J.</creator><creator>Alperi-López, M.</creator><creator>López-Soto, A.</creator><creator>Rodríguez-Rodero, S.</creator><creator>Martínez-Borra, J.</creator><creator>López-Vázquez, A.</creator><creator>Fernández-Morera, J. L.</creator><creator>Riestra-Noriega, J. L.</creator><creator>Queiro-Silva, R.</creator><creator>Quiñones-Lombraña, A.</creator><creator>López-Larrea, C.</creator><creator>González, S.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility</title><author>López-Arbesu, R. ; Ballina-García, F. J. ; Alperi-López, M. ; López-Soto, A. ; Rodríguez-Rodero, S. ; Martínez-Borra, J. ; López-Vázquez, A. ; Fernández-Morera, J. L. ; Riestra-Noriega, J. L. ; Queiro-Silva, R. ; Quiñones-Lombraña, A. ; López-Larrea, C. ; González, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-3259e79ccc79ad8ef1362163ef8f282cb65082ceba591740a6a5f06b7349698d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Histocompatibility Testing - methods</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Arbesu, R.</creatorcontrib><creatorcontrib>Ballina-García, F. J.</creatorcontrib><creatorcontrib>Alperi-López, M.</creatorcontrib><creatorcontrib>López-Soto, A.</creatorcontrib><creatorcontrib>Rodríguez-Rodero, S.</creatorcontrib><creatorcontrib>Martínez-Borra, J.</creatorcontrib><creatorcontrib>López-Vázquez, A.</creatorcontrib><creatorcontrib>Fernández-Morera, J. L.</creatorcontrib><creatorcontrib>Riestra-Noriega, J. L.</creatorcontrib><creatorcontrib>Queiro-Silva, R.</creatorcontrib><creatorcontrib>Quiñones-Lombraña, A.</creatorcontrib><creatorcontrib>López-Larrea, C.</creatorcontrib><creatorcontrib>González, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Arbesu, R.</au><au>Ballina-García, F. J.</au><au>Alperi-López, M.</au><au>López-Soto, A.</au><au>Rodríguez-Rodero, S.</au><au>Martínez-Borra, J.</au><au>López-Vázquez, A.</au><au>Fernández-Morera, J. L.</au><au>Riestra-Noriega, J. L.</au><au>Queiro-Silva, R.</au><au>Quiñones-Lombraña, A.</au><au>López-Larrea, C.</au><au>González, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>46</volume><issue>3</issue><spage>426</spage><epage>430</epage><pages>426-430</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><coden>BJRHDF</coden><abstract>Objectives. Several recent studies have shown that the MHC class III region, located telomeric to HLA-DRB1, contains an additional genetic factor that predisposes to rheumatoid arthritis (RA). In this study, we investigate whether inhibitor of κB-like (IκBL), MICB or MICA located in the MHC class III region are the second susceptibility gene associated with RA.
Methods. A total of 154 healthy controls and 140 RA patients were genotyped for HLA-DRB1, MICA, MICB and the polymorphism −62 of the IκBL gene.
Results. A significant increase of HLA-DRB1 shared epitope (SE) alleles was detected in RA patients (61.4 vs 43.5%, Pc
= 0.01, OR = 2.1, 95% CI = 1.3-3.3). Among SE alleles, the HLA-DRB1*0401 (13.5 vs 5.1%, Pc
= 0.04, OR = 3.2, 95% CI = 1.3-8.1) and HLA-DRB1*0404 (6.4 vs 1.2%, P = 0.02, Pc
= NS) showed the most significantly association with RA. No increase of risk was associated with HLA-DRB1*01. Remarkably, the allele MICB*004 was also significantly associated with RA susceptibility (40.7 vs 23.3%, Pc
= 0.01, OR = 2.2, 95% CI = 1.3-3.7). MICB*004 was in linkage disequilibrium with HLA-DRB1*0404 (λs = 0.33) and HLA-DRB1*0405 (λs = 0.34). However, MICB*004 was also increased in HLA-DRB1 SE negative patients (37 vs 21.5%, P = 0.04). No significant association between IκBL and MICA with RA was found.
Conclusions. MICB*004 allele was associated with RA susceptibility. This allele was in linkage disequilibrium with HLA-DRB1*0404 and DRB1*0405. The association of MICB with RA susceptibility and the functional role of MIC genes in the pathogenesis of RA converts MICB into a candidate to be an additional MHC gene associated with RA susceptibility.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17003176</pmid><doi>10.1093/rheumatology/kel331</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Arthritis, Rheumatoid - genetics Biological and medical sciences Diseases of the osteoarticular system Female Genetic Predisposition to Disease Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics Histocompatibility Testing - methods HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Inflammatory joint diseases Linkage Disequilibrium Male Medical sciences Middle Aged |
| title | MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility |
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