LPA4/p2y9/GPR23 Mediates Rho-dependent Morphological Changes in a Rat Neuronal Cell Line

Lysophosphatidic acid (LPA) is a potent lipid mediator that evokes a variety of biological responses in many cell types via its specific G protein-coupled receptors. In particular, LPA affects cell morphology, cell survival, and cell cycle progression in neuronal cells. Recently, we identified p2y9/...

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Veröffentlicht in:	The Journal of biological chemistry 2007-02, Vol.282 (8), p.5814-5824
Hauptverfasser:	Yanagida, Keisuke, Ishii, Satoshi, Hamano, Fumie, Noguchi, Kyoko, Shimizu, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Cadherins - genetics Cadherins - metabolism Calcium Signaling - drug effects Calcium Signaling - genetics Cell Adhesion - drug effects Cell Adhesion - genetics Cell Line, Tumor Cell Movement - drug effects Cell Movement - genetics Cell Shape - drug effects Cell Shape - genetics GTP-Binding Protein alpha Subunits, G12-G13 - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Lysophospholipids - pharmacology Neurites - metabolism Rats Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism
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