Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma
Patients with angioimmunoblastic T-cell lymphoma can have profound immune dysfunction and immunodeficiency. Epstein-Barr virus-driven B-cell lymphoid proliferation can occur in angioimmunoblastic T-cell lymphoma, as in other immunodeficiency states. However, few cases of Epstein-Barr virus-positive...
Gespeichert in:
| Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2006-11, Vol.130 (11), p.1707-1711 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1711 |
|---|---|
| container_issue | 11 |
| container_start_page | 1707 |
| container_title | Archives of pathology & laboratory medicine (1976) |
| container_volume | 130 |
| creator | Hawley, Robert C Cankovic, Milena Zarbo, Richard J |
| description | Patients with angioimmunoblastic T-cell lymphoma can have profound immune dysfunction and immunodeficiency. Epstein-Barr virus-driven B-cell lymphoid proliferation can occur in angioimmunoblastic T-cell lymphoma, as in other immunodeficiency states. However, few cases of Epstein-Barr virus-positive B-cell lymphoma arising in patients with preexisting angioimmunoblastic T-cell lymphoma have been reported. We report a case of angioimmunoblastic T-cell lymphoma in which diffuse large B-cell lymphoma developed 56 months after the diagnosis of angioimmunoblastic T-cell lymphoma. The patient survived for 9 years after the initial diagnosis of angioimmunoblastic T-cell lymphoma, and molecular studies performed on multiple biopsy specimens during this period revealed the dynamic nature of clonal lymphoid expansion. Epstein-Barr virus latent membrane protein 1 and Epstein-Barr virus-encoded RNA were detected in the diffuse large B-cell lymphoma, suggesting that Epstein-Barr virus may have played a role in the pathogenesis of the diffuse large B-cell lymphoma. |
| doi_str_mv | 10.5858/2006-130-1707-ATLWSE |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69023471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69023471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-8b45fb71d0efccf0dae98b87db5bdae2d8a0e6c7ea18d9d843ddb25ee06907eb3</originalsourceid><addsrcrecordid>eNpdkUtLxDAUhYMoOj7-gUhx4S6aR9Oky3EYHzDgwhGXIWlux0hfJq3iv7dlBkRX9174zuFyDkLnlFwLJdQNIyTDlBNMJZF4vl69Pi_30IyKlGNGM7GPZoQQjvNciSN0HOP7eOaM0UN0NEkywcUMbebNxre-roemtZWJvS-SNS6gqpLqu-7e2tokX75_S-LQQfiExjebZNnFHnyDb00IyacPQ8QmxrbwpgeXVCZsILn9a3KKDkpTRTjbzRP0crdcLx7w6un-cTFf4YJz1mNlU1FaSR2BsihK4gzkyirprLDjzpwyBLJCgqHK5U6l3DnLBADJciLB8hN0tfXtQvsxQOx17eP0iWmgHaIeMcZTSUfw8h_43g6hGX_TjNKcpDKVI5RuoSK0MQYodRd8bcK3pkRPLeipBT22oKdI9baFUXax8x5sDe5XtIud_wAn1oZM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211904747</pqid></control><display><type>article</type><title>Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma</title><source>MEDLINE</source><source>Allen Press Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hawley, Robert C ; Cankovic, Milena ; Zarbo, Richard J</creator><creatorcontrib>Hawley, Robert C ; Cankovic, Milena ; Zarbo, Richard J</creatorcontrib><description>Patients with angioimmunoblastic T-cell lymphoma can have profound immune dysfunction and immunodeficiency. Epstein-Barr virus-driven B-cell lymphoid proliferation can occur in angioimmunoblastic T-cell lymphoma, as in other immunodeficiency states. However, few cases of Epstein-Barr virus-positive B-cell lymphoma arising in patients with preexisting angioimmunoblastic T-cell lymphoma have been reported. We report a case of angioimmunoblastic T-cell lymphoma in which diffuse large B-cell lymphoma developed 56 months after the diagnosis of angioimmunoblastic T-cell lymphoma. The patient survived for 9 years after the initial diagnosis of angioimmunoblastic T-cell lymphoma, and molecular studies performed on multiple biopsy specimens during this period revealed the dynamic nature of clonal lymphoid expansion. Epstein-Barr virus latent membrane protein 1 and Epstein-Barr virus-encoded RNA were detected in the diffuse large B-cell lymphoma, suggesting that Epstein-Barr virus may have played a role in the pathogenesis of the diffuse large B-cell lymphoma.</description><identifier>ISSN: 0003-9985</identifier><identifier>EISSN: 1543-2165</identifier><identifier>DOI: 10.5858/2006-130-1707-ATLWSE</identifier><identifier>PMID: 17076535</identifier><identifier>CODEN: APLMAS</identifier><language>eng</language><publisher>United States: College of American Pathologists</publisher><subject>Aged ; Epstein-Barr virus ; Epstein-Barr Virus Infections - complications ; Fatal Outcome ; Female ; Herpesvirus 4, Human - genetics ; Humans ; Immunoblastic Lymphadenopathy - complications ; Immunoblastic Lymphadenopathy - pathology ; Lymphoma, B-Cell - chemistry ; Lymphoma, B-Cell - complications ; Lymphoma, B-Cell - pathology ; Lymphoma, B-Cell - virology ; RNA, Viral - analysis ; Viral Matrix Proteins - analysis</subject><ispartof>Archives of pathology & laboratory medicine (1976), 2006-11, Vol.130 (11), p.1707-1711</ispartof><rights>Copyright College of American Pathologists Nov 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-8b45fb71d0efccf0dae98b87db5bdae2d8a0e6c7ea18d9d843ddb25ee06907eb3</citedby><cites>FETCH-LOGICAL-c332t-8b45fb71d0efccf0dae98b87db5bdae2d8a0e6c7ea18d9d843ddb25ee06907eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17076535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawley, Robert C</creatorcontrib><creatorcontrib>Cankovic, Milena</creatorcontrib><creatorcontrib>Zarbo, Richard J</creatorcontrib><title>Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma</title><title>Archives of pathology & laboratory medicine (1976)</title><addtitle>Arch Pathol Lab Med</addtitle><description>Patients with angioimmunoblastic T-cell lymphoma can have profound immune dysfunction and immunodeficiency. Epstein-Barr virus-driven B-cell lymphoid proliferation can occur in angioimmunoblastic T-cell lymphoma, as in other immunodeficiency states. However, few cases of Epstein-Barr virus-positive B-cell lymphoma arising in patients with preexisting angioimmunoblastic T-cell lymphoma have been reported. We report a case of angioimmunoblastic T-cell lymphoma in which diffuse large B-cell lymphoma developed 56 months after the diagnosis of angioimmunoblastic T-cell lymphoma. The patient survived for 9 years after the initial diagnosis of angioimmunoblastic T-cell lymphoma, and molecular studies performed on multiple biopsy specimens during this period revealed the dynamic nature of clonal lymphoid expansion. Epstein-Barr virus latent membrane protein 1 and Epstein-Barr virus-encoded RNA were detected in the diffuse large B-cell lymphoma, suggesting that Epstein-Barr virus may have played a role in the pathogenesis of the diffuse large B-cell lymphoma.</description><subject>Aged</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Immunoblastic Lymphadenopathy - complications</subject><subject>Immunoblastic Lymphadenopathy - pathology</subject><subject>Lymphoma, B-Cell - chemistry</subject><subject>Lymphoma, B-Cell - complications</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, B-Cell - virology</subject><subject>RNA, Viral - analysis</subject><subject>Viral Matrix Proteins - analysis</subject><issn>0003-9985</issn><issn>1543-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUtLxDAUhYMoOj7-gUhx4S6aR9Oky3EYHzDgwhGXIWlux0hfJq3iv7dlBkRX9174zuFyDkLnlFwLJdQNIyTDlBNMJZF4vl69Pi_30IyKlGNGM7GPZoQQjvNciSN0HOP7eOaM0UN0NEkywcUMbebNxre-roemtZWJvS-SNS6gqpLqu-7e2tokX75_S-LQQfiExjebZNnFHnyDb00IyacPQ8QmxrbwpgeXVCZsILn9a3KKDkpTRTjbzRP0crdcLx7w6un-cTFf4YJz1mNlU1FaSR2BsihK4gzkyirprLDjzpwyBLJCgqHK5U6l3DnLBADJciLB8hN0tfXtQvsxQOx17eP0iWmgHaIeMcZTSUfw8h_43g6hGX_TjNKcpDKVI5RuoSK0MQYodRd8bcK3pkRPLeipBT22oKdI9baFUXax8x5sDe5XtIud_wAn1oZM</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Hawley, Robert C</creator><creator>Cankovic, Milena</creator><creator>Zarbo, Richard J</creator><general>College of American Pathologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma</title><author>Hawley, Robert C ; Cankovic, Milena ; Zarbo, Richard J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-8b45fb71d0efccf0dae98b87db5bdae2d8a0e6c7ea18d9d843ddb25ee06907eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - complications</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Immunoblastic Lymphadenopathy - complications</topic><topic>Immunoblastic Lymphadenopathy - pathology</topic><topic>Lymphoma, B-Cell - chemistry</topic><topic>Lymphoma, B-Cell - complications</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Lymphoma, B-Cell - virology</topic><topic>RNA, Viral - analysis</topic><topic>Viral Matrix Proteins - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawley, Robert C</creatorcontrib><creatorcontrib>Cankovic, Milena</creatorcontrib><creatorcontrib>Zarbo, Richard J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawley, Robert C</au><au>Cankovic, Milena</au><au>Zarbo, Richard J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma</atitle><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle><addtitle>Arch Pathol Lab Med</addtitle><date>2006-11</date><risdate>2006</risdate><volume>130</volume><issue>11</issue><spage>1707</spage><epage>1711</epage><pages>1707-1711</pages><issn>0003-9985</issn><eissn>1543-2165</eissn><coden>APLMAS</coden><abstract>Patients with angioimmunoblastic T-cell lymphoma can have profound immune dysfunction and immunodeficiency. Epstein-Barr virus-driven B-cell lymphoid proliferation can occur in angioimmunoblastic T-cell lymphoma, as in other immunodeficiency states. However, few cases of Epstein-Barr virus-positive B-cell lymphoma arising in patients with preexisting angioimmunoblastic T-cell lymphoma have been reported. We report a case of angioimmunoblastic T-cell lymphoma in which diffuse large B-cell lymphoma developed 56 months after the diagnosis of angioimmunoblastic T-cell lymphoma. The patient survived for 9 years after the initial diagnosis of angioimmunoblastic T-cell lymphoma, and molecular studies performed on multiple biopsy specimens during this period revealed the dynamic nature of clonal lymphoid expansion. Epstein-Barr virus latent membrane protein 1 and Epstein-Barr virus-encoded RNA were detected in the diffuse large B-cell lymphoma, suggesting that Epstein-Barr virus may have played a role in the pathogenesis of the diffuse large B-cell lymphoma.</abstract><cop>United States</cop><pub>College of American Pathologists</pub><pmid>17076535</pmid><doi>10.5858/2006-130-1707-ATLWSE</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9985 |
| ispartof | Archives of pathology & laboratory medicine (1976), 2006-11, Vol.130 (11), p.1707-1711 |
| issn | 0003-9985 1543-2165 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69023471 |
| source | MEDLINE; Allen Press Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Epstein-Barr virus Epstein-Barr Virus Infections - complications Fatal Outcome Female Herpesvirus 4, Human - genetics Humans Immunoblastic Lymphadenopathy - complications Immunoblastic Lymphadenopathy - pathology Lymphoma, B-Cell - chemistry Lymphoma, B-Cell - complications Lymphoma, B-Cell - pathology Lymphoma, B-Cell - virology RNA, Viral - analysis Viral Matrix Proteins - analysis |
| title | Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A43%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angioimmunoblastic%20T-cell%20lymphoma%20with%20supervening%20Epstein-Barr%20virus-associated%20large%20B-cell%20lymphoma&rft.jtitle=Archives%20of%20pathology%20&%20laboratory%20medicine%20(1976)&rft.au=Hawley,%20Robert%20C&rft.date=2006-11&rft.volume=130&rft.issue=11&rft.spage=1707&rft.epage=1711&rft.pages=1707-1711&rft.issn=0003-9985&rft.eissn=1543-2165&rft.coden=APLMAS&rft_id=info:doi/10.5858/2006-130-1707-ATLWSE&rft_dat=%3Cproquest_cross%3E69023471%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211904747&rft_id=info:pmid/17076535&rfr_iscdi=true |