Number of CD4+ Cells and Location of Forkhead Box Protein P3–Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome
To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance. Immunohistochemistry was used to study numbers and location of cells staining positive for immune cell markers CD4, CD7, CD8, CD25, CD68, forkhead box protein P3 (FOXP3),...
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| Veröffentlicht in: | Journal of clinical oncology 2006-11, Vol.24 (31), p.5052-5059 |
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| container_title | Journal of clinical oncology |
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| creator | LEE, Abigail M CLEAR, Andrew J GOFF, Lindsey K CALAMINICI, Maria DAVIES, Andrew J JORDAN, Suzanne MACDOUGALL, Finlay MATTHEWS, Janet NORTON, Andrew J GRIBBEN, John G LISTER, T. Andrew |
| description | To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance.
Immunohistochemistry was used to study numbers and location of cells staining positive for immune cell markers CD4, CD7, CD8, CD25, CD68, forkhead box protein P3 (FOXP3), T-cell intracellular antigen-1, and Granzyme B in tissue microarrays of paraffin-embedded, diagnostic lymph node biopsies taken from 59 FL patients who lived less than 5 years (short-survival group; n = 34) and more than 15 years (long-survival group; n = 25).
CD4 and FOXP3 expression were significantly different between the two groups. Samples from the long-survival group were more likely than those from the short-survival group to have CD4+ staining cells and to have FOXP3-positive cells in a perifollicular location.
This study has identified differences in immune cell composition of the diagnostic FL lymph node immune microenvironment and these have the potential for use as prognostic biomarkers in a routine histopathology setting. |
| doi_str_mv | 10.1200/JCO.2006.06.4642 |
| format | Article |
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Immunohistochemistry was used to study numbers and location of cells staining positive for immune cell markers CD4, CD7, CD8, CD25, CD68, forkhead box protein P3 (FOXP3), T-cell intracellular antigen-1, and Granzyme B in tissue microarrays of paraffin-embedded, diagnostic lymph node biopsies taken from 59 FL patients who lived less than 5 years (short-survival group; n = 34) and more than 15 years (long-survival group; n = 25).
CD4 and FOXP3 expression were significantly different between the two groups. Samples from the long-survival group were more likely than those from the short-survival group to have CD4+ staining cells and to have FOXP3-positive cells in a perifollicular location.
This study has identified differences in immune cell composition of the diagnostic FL lymph node immune microenvironment and these have the potential for use as prognostic biomarkers in a routine histopathology setting.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.2006.06.4642</identifier><identifier>PMID: 17033038</identifier><language>eng</language><publisher>Baltimore, MD: American Society of Clinical Oncology</publisher><subject>Biological and medical sciences ; CD4-Positive T-Lymphocytes ; Forkhead Transcription Factors - analysis ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Follicular - chemistry ; Lymphoma, Follicular - mortality ; Medical sciences ; Protein Array Analysis ; Survival Analysis ; Tumors</subject><ispartof>Journal of clinical oncology, 2006-11, Vol.24 (31), p.5052-5059</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-2ce9e64d9afca473658c0b54a960866fa201c773805d0c60333988fe2bcd3ffc3</citedby><cites>FETCH-LOGICAL-c359t-2ce9e64d9afca473658c0b54a960866fa201c773805d0c60333988fe2bcd3ffc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3729,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18281026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17033038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEE, Abigail M</creatorcontrib><creatorcontrib>CLEAR, Andrew J</creatorcontrib><creatorcontrib>GOFF, Lindsey K</creatorcontrib><creatorcontrib>CALAMINICI, Maria</creatorcontrib><creatorcontrib>DAVIES, Andrew J</creatorcontrib><creatorcontrib>JORDAN, Suzanne</creatorcontrib><creatorcontrib>MACDOUGALL, Finlay</creatorcontrib><creatorcontrib>MATTHEWS, Janet</creatorcontrib><creatorcontrib>NORTON, Andrew J</creatorcontrib><creatorcontrib>GRIBBEN, John G</creatorcontrib><creatorcontrib>LISTER, T. Andrew</creatorcontrib><title>Number of CD4+ Cells and Location of Forkhead Box Protein P3–Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance.
Immunohistochemistry was used to study numbers and location of cells staining positive for immune cell markers CD4, CD7, CD8, CD25, CD68, forkhead box protein P3 (FOXP3), T-cell intracellular antigen-1, and Granzyme B in tissue microarrays of paraffin-embedded, diagnostic lymph node biopsies taken from 59 FL patients who lived less than 5 years (short-survival group; n = 34) and more than 15 years (long-survival group; n = 25).
CD4 and FOXP3 expression were significantly different between the two groups. Samples from the long-survival group were more likely than those from the short-survival group to have CD4+ staining cells and to have FOXP3-positive cells in a perifollicular location.
This study has identified differences in immune cell composition of the diagnostic FL lymph node immune microenvironment and these have the potential for use as prognostic biomarkers in a routine histopathology setting.</description><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>Forkhead Transcription Factors - analysis</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Follicular - chemistry</subject><subject>Lymphoma, Follicular - mortality</subject><subject>Medical sciences</subject><subject>Protein Array Analysis</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU2P0zAQhi0EYsvCnRPyBTigFH_EjnOELMuHCu1hEdysqeNsvThxsROgN_4DN34evwRXjbTSSCPNPO-rGb0IPaZkSRkhLz8062XucpmrlCW7gxZUsKqoKiHuogWpOCuo4l_P0IOUbgihpeLiPjqjFeGccLVAfz9N_dZGHDrcXJQvcGO9TxiGFq-CgdGF4bi6DPHbzkKLX4dfeBPDaN2AN_zf7z-bkNzofthZmMcXDq6HkEZnssx7ZyYPEa8O_X4XesBXLqXJ4o_OxAAxwiHhJsRoPYw24S9u3OH1NJrQ24foXgc-2UdzP0efL99cNe-K1frt--bVqjBc1GPBjK2tLNsaOgNlxaVQhmxFCbUkSsoOGKGmqrgioiVG5sd5rVRn2da0vOsMP0fPTr77GL5PNo26d8nkd2CwYUpa1oRxXvEMkhOYT08p2k7vo-shHjQl-piHznnoYx461zGPLHkye0_b3ra3gjmADDydAUgGfBdhMC7dcoopSpjM3PMTt3PXu58uWp168D7bMn1jAis1p1oQwfh_yu-iOQ</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>LEE, Abigail M</creator><creator>CLEAR, Andrew J</creator><creator>GOFF, Lindsey K</creator><creator>CALAMINICI, Maria</creator><creator>DAVIES, Andrew J</creator><creator>JORDAN, Suzanne</creator><creator>MACDOUGALL, Finlay</creator><creator>MATTHEWS, Janet</creator><creator>NORTON, Andrew J</creator><creator>GRIBBEN, John G</creator><creator>LISTER, T. Andrew</creator><general>American Society of Clinical Oncology</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Number of CD4+ Cells and Location of Forkhead Box Protein P3–Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome</title><author>LEE, Abigail M ; CLEAR, Andrew J ; GOFF, Lindsey K ; CALAMINICI, Maria ; DAVIES, Andrew J ; JORDAN, Suzanne ; MACDOUGALL, Finlay ; MATTHEWS, Janet ; NORTON, Andrew J ; GRIBBEN, John G ; LISTER, T. Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-2ce9e64d9afca473658c0b54a960866fa201c773805d0c60333988fe2bcd3ffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes</topic><topic>Forkhead Transcription Factors - analysis</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Follicular - chemistry</topic><topic>Lymphoma, Follicular - mortality</topic><topic>Medical sciences</topic><topic>Protein Array Analysis</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEE, Abigail M</creatorcontrib><creatorcontrib>CLEAR, Andrew J</creatorcontrib><creatorcontrib>GOFF, Lindsey K</creatorcontrib><creatorcontrib>CALAMINICI, Maria</creatorcontrib><creatorcontrib>DAVIES, Andrew J</creatorcontrib><creatorcontrib>JORDAN, Suzanne</creatorcontrib><creatorcontrib>MACDOUGALL, Finlay</creatorcontrib><creatorcontrib>MATTHEWS, Janet</creatorcontrib><creatorcontrib>NORTON, Andrew J</creatorcontrib><creatorcontrib>GRIBBEN, John G</creatorcontrib><creatorcontrib>LISTER, T. Andrew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEE, Abigail M</au><au>CLEAR, Andrew J</au><au>GOFF, Lindsey K</au><au>CALAMINICI, Maria</au><au>DAVIES, Andrew J</au><au>JORDAN, Suzanne</au><au>MACDOUGALL, Finlay</au><au>MATTHEWS, Janet</au><au>NORTON, Andrew J</au><au>GRIBBEN, John G</au><au>LISTER, T. Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Number of CD4+ Cells and Location of Forkhead Box Protein P3–Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>24</volume><issue>31</issue><spage>5052</spage><epage>5059</epage><pages>5052-5059</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance.
Immunohistochemistry was used to study numbers and location of cells staining positive for immune cell markers CD4, CD7, CD8, CD25, CD68, forkhead box protein P3 (FOXP3), T-cell intracellular antigen-1, and Granzyme B in tissue microarrays of paraffin-embedded, diagnostic lymph node biopsies taken from 59 FL patients who lived less than 5 years (short-survival group; n = 34) and more than 15 years (long-survival group; n = 25).
CD4 and FOXP3 expression were significantly different between the two groups. Samples from the long-survival group were more likely than those from the short-survival group to have CD4+ staining cells and to have FOXP3-positive cells in a perifollicular location.
This study has identified differences in immune cell composition of the diagnostic FL lymph node immune microenvironment and these have the potential for use as prognostic biomarkers in a routine histopathology setting.</abstract><cop>Baltimore, MD</cop><pub>American Society of Clinical Oncology</pub><pmid>17033038</pmid><doi>10.1200/JCO.2006.06.4642</doi><tpages>8</tpages></addata></record> |
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| subjects | Biological and medical sciences CD4-Positive T-Lymphocytes Forkhead Transcription Factors - analysis Hematologic and hematopoietic diseases Humans Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Follicular - chemistry Lymphoma, Follicular - mortality Medical sciences Protein Array Analysis Survival Analysis Tumors |
| title | Number of CD4+ Cells and Location of Forkhead Box Protein P3–Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome |
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