Antibody-mediated p53 protein therapy prevents liver metastasis in vivo

To evaluate the clinical efficacy of monoclonal antibody (mAb) 3E10 Fv antibody-mediated p53 protein therapy, an Fv-p53 fusion protein produced in Pichia pastoris was tested on CT26.CL25 colon cancer cells in vitro and in vivo in a mouse model of colon cancer metastasis to the liver. In vitro experi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-02, Vol.67 (4), p.1769-1774
Hauptverfasser:	HANSEN, James E, FISCHER, Laurice K, REEVES, Mark E, CHAN, Grace, CHANG, Sophia S, BALDWIN, Scott W, ARAGON, Robert J, CARTER, Jacqueline J, LILLY, Michael, NISHIMURA, Robert N, WEISBART, Richard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antineoplastic agents Biological and medical sciences Cell Line, Tumor Colonic Neoplasms - immunology Colonic Neoplasms - therapy Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoglobulin Fragments - genetics Immunoglobulin Fragments - immunology Immunoglobulin Fragments - pharmacology Liver Neoplasms, Experimental - immunology Liver Neoplasms, Experimental - prevention & control Liver Neoplasms, Experimental - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Inbred BALB C Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy Pharmacology. Drug treatments Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - pharmacology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - immunology Tumor Suppressor Protein p53 - pharmacology Tumors
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