Influence of follicular fluid meiosis-activating sterol on aneuploidy rate and precocious chromatid segregation in aged mouse oocytes

BACKGROUND: Follicular fluid meiosis-activating sterol (FF-MAS) protects young oocytes from precocious chromatid separation (predivision). Reduced expression of cohesion and checkpoint proteins and predivision has been hypothesized to occur in age-related aneuploidy in oocytes. METHODS: To know whet...

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Veröffentlicht in:	Human reproduction (Oxford) 2007-03, Vol.22 (3), p.815-828
Hauptverfasser:	Cukurcam, S., Betzendahl, I., Michel, G., Vogt, E., Hegele-Hartung, C., Lindenthal, B., Eichenlaub-Ritter, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	age Aging Animals Biological and medical sciences Cell Cycle Proteins - biosynthesis Cellular Senescence Cholestenes - pharmacology Chromatids - physiology Chromosome Segregation - drug effects Chromosome Segregation - physiology Female Gynecology. Andrology. Obstetrics Hypoxanthine - pharmacology Mad2 Proteins maturation Medical sciences meiosis Meiosis - drug effects Mice Mice, Inbred CBA non-disjunction oocyte Oocytes - physiology Organic Chemicals Polyploidy
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