TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway

Transferrin receptor 2 (TfR2) possesses a YQRV motif similar to the YTRF motif of transferrin receptor 1 (TfR1) responsible for the internalization and secretion through the endosomal pathway. Raft biochemical dissection showed that TfR2 is a component of the low-density Triton-insoluble (LDTI) plas...

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Veröffentlicht in:	Journal of cell science 2006-11, Vol.119 (21), p.4486-4498
Hauptverfasser:	Calzolari, Alessia, Raggi, Carla, Deaglio, Silvia, Sposi, Nadia Maria, Stafsnes, Marit, Fecchi, Katia, Parolini, Isabella, Malavasi, Fabio, Peschle, Cesare, Sargiacomo, Massimo, Testa, Ugo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Blotting, Western Carcinoma, Hepatocellular - metabolism Caveolin 1 - metabolism Cell Membrane - metabolism Cells, Cultured - metabolism Endocytosis Flow Cytometry Humans Immunoprecipitation K562 Cells - metabolism Liver Neoplasms - metabolism Membrane Microdomains - metabolism Mitogen-Activated Protein Kinases - metabolism Phosphorylation Receptors, Transferrin - genetics Receptors, Transferrin - metabolism Signal Transduction Subcellular Fractions Tetraspanin 28 Transport Vesicles - metabolism
Online-Zugang:	Volltext
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