CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling

It was originally thought that the critical role of the CD40 ligand (CD40L) in normal and inflammatory immune responses was mainly mediated through its interaction with the classic receptor, CD40. However, data from CD40L(-/-) and CD40(-/-) mice suggest that the CD40L-induced inflammatory immune res...

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Veröffentlicht in:	The Journal of biological chemistry 2007-02, Vol.282 (8), p.5143-5151
Hauptverfasser:	Léveillé, Claire, Bouillon, Marlène, Guo, Wen, Bolduc, Julie, Sharif-Askari, Ehssan, El-Fakhry, Youssef, Reyes-Moreno, Carlos, Lapointe, Rejean, Merhi, Yahye, Wilkins, John A, Mourad, Walid
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology CD40 Antigens - deficiency CD40 Antigens - immunology CD40 Ligand - immunology Gene Expression Regulation - immunology Humans Inflammation - immunology Integrin alpha5beta1 - immunology Interleukin-8 - immunology MAP Kinase Signaling System - immunology Mice Mice, Knockout Mitogen-Activated Protein Kinase 1 - immunology Mitogen-Activated Protein Kinase 3 - immunology Platelet Glycoprotein GPIIb-IIIa Complex - immunology Protein Binding - immunology Protein Transport - immunology U937 Cells
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