Characterization and Comparison of Nicotine and Cotinine Metabolism in Vitro and in Vivo in DBA/2 and C57BL/6 Mice

DBA/2 and C57BL/6 are two commonly used mouse strains that differ in response to nicotine. Previous studies have shown that the nicotine-metabolizing enzyme CYP2A5 differs in coumarin metabolism between these two strains, suggesting differences in nicotine metabolism. Nicotine was metabolized to cot...

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Veröffentlicht in:	Molecular pharmacology 2007-03, Vol.71 (3), p.826-834
Hauptverfasser:	Siu, Eric C.K., Tyndale, Rachel F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Aryl Hydrocarbon Hydroxylases - physiology Chromatography, Liquid Cotinine - analogs & derivatives Cotinine - analysis Cotinine - metabolism Cytochrome P-450 CYP2A6 Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P450 Family 2 Male Mass Spectrometry Mice Mice, Inbred C57BL Mice, Inbred DBA Mixed Function Oxygenases - antagonists & inhibitors Mixed Function Oxygenases - physiology Nicotine - metabolism Oxidation-Reduction Oxidoreductases, N-Demethylating - antagonists & inhibitors Species Specificity
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