Bayesian evaluation of group sequential clinical trial designs

Clinical trial designs often incorporate a sequential stopping rule to serve as a guide in the early termination of a study. When choosing a particular stopping rule, it is most common to examine frequentist operating characteristics such as type I error, statistical power, and precision of confiden...

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Veröffentlicht in:	Statistics in medicine 2007-03, Vol.26 (7), p.1431-1449
Hauptverfasser:	Emerson, Scott S., Kittelson, John M., Gillen, Daniel L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - therapeutic use Bayes Theorem Bayesian Bayesian analysis Clinical trials Data Interpretation, Statistical Double-Blind Method Endotoxins - immunology Gram-Negative Bacterial Infections - mortality Gram-Negative Bacterial Infections - therapy Humans interim analyses Medical statistics operating characteristics Probability Randomized Controlled Trials as Topic - methods sample size Sepsis - mortality Sepsis - therapy stopping rules
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