ABCA1 Overexpression in the Liver of LDLr-KO Mice Leads to Accumulation of Pro-atherogenic Lipoproteins and Enhanced Atherosclerosis

The identification of ABCA1 as a key transporter responsible for cellular lipid efflux has led to considerable interest in defining its role in cholesterol metabolism and atherosclerosis. In this study, the effect of overexpressing ABCA1 in the liver of LDLr-KO mice was investigated. Compared with L...

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Veröffentlicht in:	The Journal of biological chemistry 2006-11, Vol.281 (44), p.33053-33065
Hauptverfasser:	Joyce, Charles W., Wagner, Elke M., Basso, Federica, Amar, Marcelo J., Freeman, Lita A., Shamburek, Robert D., Knapper, Catherine L., Syed, Jafri, Wu, Justina, Vaisman, Boris L., Fruchart-Najib, Jamila, Billings, Eric M., Paigen, Beverly, Remaley, Alan T., Santamarina-Fojo, Silvia, Brewer, H. Bryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Aorta - pathology Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biliary Tract - metabolism Cholesterol - blood Disease Progression Feces Female Gene Expression Regulation Hemostasis Humans Intestinal Mucosa - metabolism Lipid Metabolism Lipoproteins - metabolism Liver - metabolism Mice Mice, Transgenic Oligonucleotide Array Sequence Analysis Organ Specificity Receptors, LDL - deficiency Receptors, LDL - genetics Receptors, LDL - metabolism Sterols - metabolism
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