α-Lipoic Acid as a Directly Binding Activator of the Insulin Receptor: Protection from Hepatocyte Apoptosis

Background and aim: α-Lipoic acid has cytoprotective potential which has previously been explained by its antioxidant properties. The aim of this study was to assess LA-induced-specific cytoprotective signalling pathways in hepatocytes. Methods: Apoptosis of rat hepatocytes was induced by actinomy...

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Veröffentlicht in:	Biochemistry (Easton) 2007-02, Vol.46 (8), p.2146-2155
Hauptverfasser:	Diesel, Britta, Kulhanek-Heinze, Stefanie, Höltje, Monika, Brandt, Birte, Höltje, Hans-Dieter, Vollmar, Angelika M, Kiemer, Alexandra K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Apoptosis - drug effects Cells, Cultured Dactinomycin - pharmacology Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Insulin - metabolism Male Models, Molecular Oncogene Protein v-akt - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein Structure, Tertiary Rats Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases - metabolism Receptor, Insulin - metabolism Signal Transduction Thioctic Acid - metabolism Thioctic Acid - pharmacology Tumor Necrosis Factor-alpha - pharmacology
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