Changes in cholesterol levels in the plasma membrane modulate cell signaling and regulate cell adhesion and migration on fibronectin

The number and distribution of lipid molecules, including cholesterol in particular, in the plasma membrane, may play a key role in regulating several physiological processes in cells. We investigated the role of membrane cholesterol in regulating cell shape, adhesion and motility. The acute depleti...

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Veröffentlicht in:	Cell motility and the cytoskeleton 2007-03, Vol.64 (3), p.199-216
Hauptverfasser:	Ramprasad, O. G., Srinivas, G., Rao, K. Sridhar, Joshi, Powrnima, Thiery, Jean Paul, Dufour, Sylvie, Pande, Gopal
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actins - metabolism adhesion Animals Cell Adhesion Cell Line, Tumor Cell Membrane - enzymology Cell Membrane - metabolism Cell Movement Cholesterol - deficiency Cholesterol - metabolism Cytoskeleton - enzymology Cytoskeleton - metabolism Enzyme Activation Erk1/Erk2 MAP‐kinase extracellular matrix FAK Fibronectins - metabolism Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans integrin Integrin alpha5beta1 - metabolism lipids Mice migration Mitogen-Activated Protein Kinases - metabolism Paxillin - metabolism Phosphorylation Protein Transport Signal Transduction
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