Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration

Caspases are a conserved family of cell death proteases that cleave intracellular substrates at Asp residues to modify their function and promote apoptosis. In this report we identify the integrin beta4 subunit as a novel caspase substrate using an expression cloning strategy. Together with its alph...

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Veröffentlicht in:	The Journal of biological chemistry 2007-02, Vol.282 (8), p.5560-5569
Hauptverfasser:	Werner, Michael E, Chen, Feng, Moyano, Jose V, Yehiely, Fruma, Jones, Jonathan C R, Cryns, Vincent L
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Caspase 3 - metabolism Caspase 7 - metabolism Cell Adhesion - physiology Cell Line, Tumor Cell Movement - physiology Cell Survival - physiology Epithelial Cells - enzymology Hemidesmosomes - metabolism Humans Integrin alpha6beta4 - metabolism Integrin beta4 - metabolism Proteasome Endopeptidase Complex - metabolism
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