Mapping the amphetamine-evoked changes in [11C]raclopride binding in living rat using small animal PET: Modulation by MAO-inhibition

The performance of small animal PET for neuroreceptor studies in a psychopharmacological challenge paradigm is not yet well-described. Therefore, we used microPET and [11C]raclopride to map the availability of dopamine D2/3 receptors in brain of anesthetized rats, first in a baseline condition, and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2007-03, Vol.35 (1), p.38-46
Hauptverfasser:	Pedersen, Kasper, Simonsen, Mette, Østergaard, Søren D., Lajord Munk, Ole, Rosa-Neto, Pedro, Olsen, Aage Kristian, Jensen, Svend Borup, Møller, Arne, Cumming, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine Amphetamine - pharmacology Animals Binding sites Brain - diagnostic imaging Brain Chemistry - drug effects Brain Mapping Competition Dopamine Dopamine Antagonists - pharmacokinetics Dopamine Uptake Inhibitors - pharmacology Drug dosages Functional Laterality - physiology Hypotheses Image Processing, Computer-Assisted Male microPET Monoamine Oxidase Inhibitors - pharmacology Neostriatum - metabolism Pargyline Pargyline - pharmacology Positron-Emission Tomography Raclopride Raclopride - pharmacokinetics Rats Rats, Inbred Lew Rodents Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!