Effect of TGF-β/Smad signaling pathway on lung myofibroblast differentiation

Aim：Myofibroblasts play important roles in the pathogenesis of lung fibrosis. Transforming growth factor （TGF）-β1 has been widely recognized as a key fibrogenic cytokine. The major signaling pathway of TGF-β1 is through cytoplasmic Smad proteins. Our study investigated the role of individual TGF-β1/...

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Veröffentlicht in:	Acta pharmacologica Sinica 2007-03, Vol.28 (3), p.382-391
Hauptverfasser:	Gu, Li, Zhu, Yuan-Jue, Yang, Xiao, Guo, Zi-Jian, Xu, Wen-Bing, Tian, Xin-Lun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Fibroblasts - physiology Genes, Reporter - genetics Humans Lung - cytology Mice Plasmids - genetics Signal Transduction - genetics Signal Transduction - physiology Smad Proteins - genetics Smad Proteins - physiology Smad3 Protein - biosynthesis Smad3 Protein - genetics TGF-β/Smad信号转导通路 Transfection Transforming Growth Factor beta - genetics Transforming Growth Factor beta - physiology α-平滑肌肌动蛋白细胞分化肌成纤维细胞肺纤维化转化生长因子-β1
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