A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE

We have developed a number of hydroxamate and non-hydroxamate inhibitors of TACE that possess the selective quinolinemethoxy P1′ group. Using the X-ray co-crystal structure of our hydroxamate IK682 and TACE, and a co-crystal structure of a pyrimidinetrione in MMP-8, we have developed a highly plausi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-03, Vol.17 (5), p.1408-1412
Hauptverfasser:	Sheppeck, James E., Tebben, Andrew, Gilmore, John L., Yang, Anle, Wasserman, Zelda R., Decicco, Carl P., Duan, James J.-W.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - antagonists & inhibitors ADAM Proteins - chemistry ADAM17 Protein Barbiturate Binding Sites Biological and medical sciences Humans Hydantoin Hydantoins - chemistry Hydantoins - pharmacology Hydroxamate Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Lactams - chemistry Lactams - pharmacology Medical sciences Metalloprotease Metalloproteinase Miscellaneous MMP Modeling Models, Molecular Molecular Conformation Non-hydroxamate Pharmacology. Drug treatments Pyrimidinones - chemistry Pyrimidinones - pharmacology Structure-Activity Relationship TACE TACE inhibitor TNF Zinc - chemistry
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