Overcoming maternal antibody interference by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of swine influenza virus

Sows and gilts lack immunity to human adenovirus 5 (Ad-5) vectored vaccines so immunogens of swine pathogens can be expressed with these vaccines in order to immunize suckling piglets that have interfering, maternally derived antibodies. In this study 7-day-old piglets, that had suckled H3N2 infecte...

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Veröffentlicht in:	Veterinary microbiology 2006-11, Vol.118 (1), p.67-75
Hauptverfasser:	Wesley, Ronald D., Lager, Kelly M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ad-5 vaccines Adenoviruses, Human - immunology Animals antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Applied microbiology Biological and medical sciences disease course disease severity Female Fundamental and applied biological sciences. Psychology Genetic Vectors gilts hemagglutination inhibition test Hemagglutination Inhibition Tests - veterinary hemagglutinins Hemagglutinins - immunology Human adenovirus 5 Human adenovirus C Humans immune response Influenza A virus Influenza A virus - immunology Influenza A Virus, H3N2 Subtype Influenza Vaccines - immunology live vaccines Mastadenovirus Maternal antibody interference maternal immunity Microbiology Miscellaneous nucleoproteins Nucleoproteins - genetics Nucleoproteins - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - veterinary Orthomyxoviridae Infections - virology pathogen shedding piglets Random Allocation recombinant vaccines signs and symptoms (animals and humans) Simian immunodeficiency virus sows Swine swine diseases Swine Diseases - immunology Swine Diseases - prevention & control Swine Diseases - virology Swine influenza virus vaccination Vaccination - veterinary Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic Virology virulence
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