Notch Ligand Delta-Like 1 Is Essential for Postnatal Arteriogenesis

Growth of functional arteries is essential for the restoration of blood flow to ischemic organs. Notch signaling regulates arterial differentiation upstream of ephrin-B2 during embryonic development, but its role during postnatal arteriogenesis is unknown. Here, we identify the Notch ligand Delta-li...

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Veröffentlicht in:	Circulation research 2007-02, Vol.100 (3), p.363-371
Hauptverfasser:	Limbourg, Anne, Ploom, Merlin, Elligsen, Diana, Sörensen, Inga, Ziegelhoeffer, Tibor, Gossler, Achim, Drexler, Helmut, Limbourg, Florian P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Arteries - chemistry Arteries - cytology Arteries - growth & development Biological and medical sciences Capillaries - chemistry Cells, Cultured - drug effects Cells, Cultured - metabolism Collateral Circulation - physiology Constriction Culture Media, Serum-Free Endothelial Cells - metabolism Endothelium, Vascular - cytology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Gene Silencing Hindlimb - blood supply Humans Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - physiology Ischemia - etiology Ischemia - genetics Ischemia - physiopathology Membrane Proteins - physiology Mice Mice, Transgenic Morphogenesis - genetics Morphogenesis - physiology Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology Organ Specificity Receptor, EphB2 - biosynthesis Receptor, EphB2 - genetics Receptor, EphB2 - physiology Receptor, EphB4 - biosynthesis Receptor, EphB4 - genetics Receptor, EphB4 - physiology Receptors, Notch - physiology RNA, Small Interfering - pharmacology Veins - chemistry Vertebrates: cardiovascular system
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