Nasal bone assessment in prenatal screening for trisomy 21
A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that nasal bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both nas...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2006-11, Vol.195 (5), p.1219-1230 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Sonek, J.D. Cicero, S. Neiger, R. Nicolaides, K.H. |
| description | A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that nasal bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both nasal bone absence and short nasal bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal nasal bone in screening for trisomy 21. |
| doi_str_mv | 10.1016/j.ajog.2005.11.042 |
| format | Article |
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Evidence based on radiologic, histomorphologic, and sonographic studies shows that nasal bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both nasal bone absence and short nasal bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal nasal bone in screening for trisomy 21.</description><subject>Biological and medical sciences</subject><subject>Chromosomal defects</subject><subject>Chromosome aberrations</subject><subject>Down Syndrome - diagnostic imaging</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Histomorphology</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Nasal Bone - abnormalities</subject><subject>Nasal Bone - diagnostic imaging</subject><subject>Nasal Bone - embryology</subject><subject>Nasal bone absence</subject><subject>Nasal bone hypoplasia</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy Trimester, Third</subject><subject>Prenatal screening</subject><subject>Trisomy 21</subject><subject>Ultrasonography, Prenatal</subject><subject>Ultrasound</subject><subject>X-ray</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSTZp_0AOwZf0ZmdGtmUp5FJC8wGhvSRnodWOghZb3mi8hfz7etmFvfU0DPO8L8MjxCVChYDqZl259fheSYC2QqygkSdigWC6Ummlv4gFAMjS1J0-E-fM690qjTwVZ6gUtkbKhbj97dj1xXJMVDhmYh4oTUVMxSZTctN8Y5-JUkzvRRhzMeXI4_BZSPwmvgbXM30_zAvx9vDr9f6pfPnz-Hz_86X0tW6mMtTYLdEtTaNUAw4NBA-1lxhaDKsmaN91QWPQmkztgm-8k20ITmPXShOgvhA_9r2bPH5siSc7RPbU9y7RuGWrDGADtZ5BuQd9HpkzBbvJcXD50yLYnTG7tjtjdmfMItrZ2By6OrRvlwOtjpGDohm4PgCOvetDdslHPnJaGlBdPXN3e45mF38jZcs-UvK0ipn8ZFdj_N8f_wCx74iF</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Sonek, J.D.</creator><creator>Cicero, S.</creator><creator>Neiger, R.</creator><creator>Nicolaides, K.H.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Nasal bone assessment in prenatal screening for trisomy 21</title><author>Sonek, J.D. ; Cicero, S. ; Neiger, R. ; Nicolaides, K.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-f317b1ab946640a190fc03c21f51fd4f8c77f81f88e93afc4ca25ffa817529f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Chromosomal defects</topic><topic>Chromosome aberrations</topic><topic>Down Syndrome - diagnostic imaging</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Histomorphology</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Nasal Bone - abnormalities</topic><topic>Nasal Bone - diagnostic imaging</topic><topic>Nasal Bone - embryology</topic><topic>Nasal bone absence</topic><topic>Nasal bone hypoplasia</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy Trimester, Third</topic><topic>Prenatal screening</topic><topic>Trisomy 21</topic><topic>Ultrasonography, Prenatal</topic><topic>Ultrasound</topic><topic>X-ray</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonek, J.D.</creatorcontrib><creatorcontrib>Cicero, S.</creatorcontrib><creatorcontrib>Neiger, R.</creatorcontrib><creatorcontrib>Nicolaides, K.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonek, J.D.</au><au>Cicero, S.</au><au>Neiger, R.</au><au>Nicolaides, K.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nasal bone assessment in prenatal screening for trisomy 21</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>195</volume><issue>5</issue><spage>1219</spage><epage>1230</epage><pages>1219-1230</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that nasal bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both nasal bone absence and short nasal bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal nasal bone in screening for trisomy 21.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>16615922</pmid><doi>10.1016/j.ajog.2005.11.042</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 2006-11, Vol.195 (5), p.1219-1230 |
| issn | 0002-9378 1097-6868 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Chromosomal defects Chromosome aberrations Down Syndrome - diagnostic imaging Female Gestational Age Gynecology. Andrology. Obstetrics Histomorphology Humans Imaging, Three-Dimensional Medical genetics Medical sciences Nasal Bone - abnormalities Nasal Bone - diagnostic imaging Nasal Bone - embryology Nasal bone absence Nasal bone hypoplasia Pregnancy Pregnancy Trimester, Second Pregnancy Trimester, Third Prenatal screening Trisomy 21 Ultrasonography, Prenatal Ultrasound X-ray |
| title | Nasal bone assessment in prenatal screening for trisomy 21 |
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