Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

The renal angiotensin angiotensin type 2 receptor has been shown to mediate natriuresis, and angiotensin III, not angiotensin II, may be the preferential angiotensin type 2 receptor activator of this response. Angiotensin III is metabolized to angiotensin IV by aminopeptidase N. The present study hy...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-03, Vol.49 (3, Part 2 Suppl), p.625-630
Hauptverfasser:	Padia, Shetal H, Kemp, Brandon A, Howell, Nancy L, Siragy, Helmy M, Fournie-Zaluski, Marie-Claude, Roques, Bernard P, Carey, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin III - pharmacology Animals Arterial hypertension. Arterial hypotension Benzimidazoles - administration & dosage Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system CD13 Antigens - antagonists & inhibitors Clinical manifestations. Epidemiology. Investigative techniques. Etiology Enzyme Inhibitors - pharmacology Experimental diseases Medical sciences Methionine - analogs & derivatives Methionine - pharmacology Models, Animal Natriuresis - drug effects Natriuretic Agents - pharmacology Rats Rats, Sprague-Dawley Receptors, Angiotensin - drug effects Sodium - urine Tetrazoles - administration & dosage
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