Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia
Objective The objectives are to delineate the nature of subsyndromal depressive symptoms (SSD) in midlife and older patients with schizophrenia and schizoaffective disorder by: 1) describing the relationship of SSD with a number of other clinical features; and 2) examining which specific depressive...
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| Veröffentlicht in: | The American journal of geriatric psychiatry 2007-12, Vol.15 (12), p.1005-1014 |
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| creator | Zisook, Sidney, M.D Montross, Lori, Ph.D Kasckow, John, M.D Mohamed, Somaia, M.D Palmer, Barton W., Ph.D Patterson, Thomas L., Ph.D Golshan, Shahrokh, Ph.D Fellows, Ian, M.S Lehman, David, M.D Solorzano, Ellen, B.A |
| description | Objective The objectives are to delineate the nature of subsyndromal depressive symptoms (SSD) in midlife and older patients with schizophrenia and schizoaffective disorder by: 1) describing the relationship of SSD with a number of other clinical features; and 2) examining which specific depressive symptoms are increased in patients broadly defined as having SSD. Methods A total of 204 participants with schizophrenia or schizoaffective disorder and SSD who entered a federally funded intervention study at the University of California San Diego (UCSD) and University of Cincinnati were matched with schizophrenic and schizoaffective participants from the Geriatric Research Center at UCSD who had minimal or no depressive symptoms. The SSD and no depression groups were compared on a variety of clinical features including general psychopathology, positive and negative symptoms, medical and mental functioning, cognition, movement abnormalities, and specific depressive symptomatology. Results SSD was associated with increases in overall psychopathology; positive and negative symptoms; severity of general medical conditions; impaired physical and mental functioning; possibly more severe akathisia; and more depressive symptoms throughout the spectrum of symptom clusters measured by the Hamilton Depression Rating Scale, including anxiety and suicidality. Conclusions SSD in middle aged and older patients with schizophrenia is an important clinical dimension that appears to be associated with substantial morbidity and distress. The findings suggest that is important for clinicians to look for and assess subsyndromal depressive symptoms in patients with chronic schizophrenia. |
| doi_str_mv | 10.1097/JGP.0b013e3180a725ec |
| format | Article |
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Methods A total of 204 participants with schizophrenia or schizoaffective disorder and SSD who entered a federally funded intervention study at the University of California San Diego (UCSD) and University of Cincinnati were matched with schizophrenic and schizoaffective participants from the Geriatric Research Center at UCSD who had minimal or no depressive symptoms. The SSD and no depression groups were compared on a variety of clinical features including general psychopathology, positive and negative symptoms, medical and mental functioning, cognition, movement abnormalities, and specific depressive symptomatology. Results SSD was associated with increases in overall psychopathology; positive and negative symptoms; severity of general medical conditions; impaired physical and mental functioning; possibly more severe akathisia; and more depressive symptoms throughout the spectrum of symptom clusters measured by the Hamilton Depression Rating Scale, including anxiety and suicidality. Conclusions SSD in middle aged and older patients with schizophrenia is an important clinical dimension that appears to be associated with substantial morbidity and distress. The findings suggest that is important for clinicians to look for and assess subsyndromal depressive symptoms in patients with chronic schizophrenia.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1097/JGP.0b013e3180a725ec</identifier><identifier>PMID: 18056819</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Age Factors ; Chronic Disease ; Citalopram - therapeutic use ; Comorbidity ; Depression - diagnosis ; Depression - epidemiology ; Depression - psychology ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Depressive Disorder, Major - psychology ; Depressive symptoms ; Double-Blind Method ; Female ; Follow-Up Studies ; Health Status ; Humans ; Internal Medicine ; Male ; Middle Aged ; Placebos ; Psychiatric Status Rating Scales - statistics & numerical data ; Psychotic Disorders - diagnosis ; Psychotic Disorders - epidemiology ; Psychotic Disorders - psychology ; schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - epidemiology ; Schizophrenic Psychology ; Serotonin Uptake Inhibitors - therapeutic use ; subsyndromal depression ; Suicide - psychology ; Suicide - statistics & numerical data ; Treatment Outcome</subject><ispartof>The American journal of geriatric psychiatry, 2007-12, Vol.15 (12), p.1005-1014</ispartof><rights>American Association for Geriatric Psychiatry</rights><rights>2007 American Association for Geriatric Psychiatry</rights><rights>Copyright American Psychiatric Publishing, Inc. Dec 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-940d8493019a72f9f965072387d546832214bd37f1f7230d65a08fd951d686cc3</citedby><cites>FETCH-LOGICAL-c442t-940d8493019a72f9f965072387d546832214bd37f1f7230d65a08fd951d686cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18056819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zisook, Sidney, M.D</creatorcontrib><creatorcontrib>Montross, Lori, Ph.D</creatorcontrib><creatorcontrib>Kasckow, John, M.D</creatorcontrib><creatorcontrib>Mohamed, Somaia, M.D</creatorcontrib><creatorcontrib>Palmer, Barton W., Ph.D</creatorcontrib><creatorcontrib>Patterson, Thomas L., Ph.D</creatorcontrib><creatorcontrib>Golshan, Shahrokh, Ph.D</creatorcontrib><creatorcontrib>Fellows, Ian, M.S</creatorcontrib><creatorcontrib>Lehman, David, M.D</creatorcontrib><creatorcontrib>Solorzano, Ellen, B.A</creatorcontrib><title>Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia</title><title>The American journal of geriatric psychiatry</title><addtitle>Am J Geriatr Psychiatry</addtitle><description>Objective The objectives are to delineate the nature of subsyndromal depressive symptoms (SSD) in midlife and older patients with schizophrenia and schizoaffective disorder by: 1) describing the relationship of SSD with a number of other clinical features; and 2) examining which specific depressive symptoms are increased in patients broadly defined as having SSD. Methods A total of 204 participants with schizophrenia or schizoaffective disorder and SSD who entered a federally funded intervention study at the University of California San Diego (UCSD) and University of Cincinnati were matched with schizophrenic and schizoaffective participants from the Geriatric Research Center at UCSD who had minimal or no depressive symptoms. The SSD and no depression groups were compared on a variety of clinical features including general psychopathology, positive and negative symptoms, medical and mental functioning, cognition, movement abnormalities, and specific depressive symptomatology. Results SSD was associated with increases in overall psychopathology; positive and negative symptoms; severity of general medical conditions; impaired physical and mental functioning; possibly more severe akathisia; and more depressive symptoms throughout the spectrum of symptom clusters measured by the Hamilton Depression Rating Scale, including anxiety and suicidality. Conclusions SSD in middle aged and older patients with schizophrenia is an important clinical dimension that appears to be associated with substantial morbidity and distress. The findings suggest that is important for clinicians to look for and assess subsyndromal depressive symptoms in patients with chronic schizophrenia.</description><subject>Age Factors</subject><subject>Chronic Disease</subject><subject>Citalopram - therapeutic use</subject><subject>Comorbidity</subject><subject>Depression - diagnosis</subject><subject>Depression - epidemiology</subject><subject>Depression - psychology</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Depressive symptoms</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Status</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Placebos</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Psychotic Disorders - psychology</subject><subject>schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenic Psychology</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>subsyndromal depression</subject><subject>Suicide - psychology</subject><subject>Suicide - statistics & numerical data</subject><subject>Treatment Outcome</subject><issn>1064-7481</issn><issn>1545-7214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUFv1DAQhS0EoqXwDxCKOHBLGSe2Y1-QqgIFVNRKW86W156wLokd7KRo-fV4tStV2gu-2LK-NzPvDSGvKZxTUN37b1e357AG2mJLJZiu4WifkFPKGa-7hrKn5Q2C1R2T9IS8yPkeAIQS7Dk5KQIuJFWn5G61rPM2uBRHM1QfcUqYs3_AarUdpzmOufKh-u6dG7C--ImuMsFVN4PDVN1iyjHk6o-fN9XKbvzfOG0SBm9ekme9GTK-Otxn5MfnT3eXX-rrm6uvlxfXtWWsmWvFwEmmWqCqjN-rXgkOXdPKznEmZNsUF2vXdj3tyy84wQ3I3ilOnZDC2vaMvNvXnVL8vWCe9eizxWEwAeOStVBAG6FYAd8egfdxSaHMpqniSgre7SC2h2yKOSfs9ZT8aNJWU9C7yHWJXB9HXmRvDrWX9YjuUXTIuAAf9gCWKB48Jp2tx2DR-YR21i76_3U4LmAHH7w1wy_cYn60onOjQa92a99tvXgHUU77D9DzpZs</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Zisook, Sidney, M.D</creator><creator>Montross, Lori, Ph.D</creator><creator>Kasckow, John, M.D</creator><creator>Mohamed, Somaia, M.D</creator><creator>Palmer, Barton W., Ph.D</creator><creator>Patterson, Thomas L., Ph.D</creator><creator>Golshan, Shahrokh, Ph.D</creator><creator>Fellows, Ian, M.S</creator><creator>Lehman, David, M.D</creator><creator>Solorzano, Ellen, B.A</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>4T-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia</title><author>Zisook, Sidney, M.D ; Montross, Lori, Ph.D ; Kasckow, John, M.D ; Mohamed, Somaia, M.D ; Palmer, Barton W., Ph.D ; Patterson, Thomas L., Ph.D ; Golshan, Shahrokh, Ph.D ; Fellows, Ian, M.S ; Lehman, David, M.D ; Solorzano, Ellen, B.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-940d8493019a72f9f965072387d546832214bd37f1f7230d65a08fd951d686cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Age Factors</topic><topic>Chronic Disease</topic><topic>Citalopram - therapeutic use</topic><topic>Comorbidity</topic><topic>Depression - diagnosis</topic><topic>Depression - epidemiology</topic><topic>Depression - psychology</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Depressive symptoms</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Status</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Placebos</topic><topic>Psychiatric Status Rating Scales - statistics & numerical data</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - epidemiology</topic><topic>Psychotic Disorders - psychology</topic><topic>schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenic Psychology</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>subsyndromal depression</topic><topic>Suicide - psychology</topic><topic>Suicide - statistics & numerical data</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zisook, Sidney, M.D</creatorcontrib><creatorcontrib>Montross, Lori, Ph.D</creatorcontrib><creatorcontrib>Kasckow, John, M.D</creatorcontrib><creatorcontrib>Mohamed, Somaia, M.D</creatorcontrib><creatorcontrib>Palmer, Barton W., Ph.D</creatorcontrib><creatorcontrib>Patterson, Thomas L., Ph.D</creatorcontrib><creatorcontrib>Golshan, Shahrokh, Ph.D</creatorcontrib><creatorcontrib>Fellows, Ian, M.S</creatorcontrib><creatorcontrib>Lehman, David, M.D</creatorcontrib><creatorcontrib>Solorzano, Ellen, B.A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zisook, Sidney, M.D</au><au>Montross, Lori, Ph.D</au><au>Kasckow, John, M.D</au><au>Mohamed, Somaia, M.D</au><au>Palmer, Barton W., Ph.D</au><au>Patterson, Thomas L., Ph.D</au><au>Golshan, Shahrokh, Ph.D</au><au>Fellows, Ian, M.S</au><au>Lehman, David, M.D</au><au>Solorzano, Ellen, B.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia</atitle><jtitle>The American journal of geriatric psychiatry</jtitle><addtitle>Am J Geriatr Psychiatry</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>15</volume><issue>12</issue><spage>1005</spage><epage>1014</epage><pages>1005-1014</pages><issn>1064-7481</issn><eissn>1545-7214</eissn><abstract>Objective The objectives are to delineate the nature of subsyndromal depressive symptoms (SSD) in midlife and older patients with schizophrenia and schizoaffective disorder by: 1) describing the relationship of SSD with a number of other clinical features; and 2) examining which specific depressive symptoms are increased in patients broadly defined as having SSD. Methods A total of 204 participants with schizophrenia or schizoaffective disorder and SSD who entered a federally funded intervention study at the University of California San Diego (UCSD) and University of Cincinnati were matched with schizophrenic and schizoaffective participants from the Geriatric Research Center at UCSD who had minimal or no depressive symptoms. The SSD and no depression groups were compared on a variety of clinical features including general psychopathology, positive and negative symptoms, medical and mental functioning, cognition, movement abnormalities, and specific depressive symptomatology. Results SSD was associated with increases in overall psychopathology; positive and negative symptoms; severity of general medical conditions; impaired physical and mental functioning; possibly more severe akathisia; and more depressive symptoms throughout the spectrum of symptom clusters measured by the Hamilton Depression Rating Scale, including anxiety and suicidality. Conclusions SSD in middle aged and older patients with schizophrenia is an important clinical dimension that appears to be associated with substantial morbidity and distress. The findings suggest that is important for clinicians to look for and assess subsyndromal depressive symptoms in patients with chronic schizophrenia.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>18056819</pmid><doi>10.1097/JGP.0b013e3180a725ec</doi><tpages>10</tpages></addata></record> |
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| subjects | Age Factors Chronic Disease Citalopram - therapeutic use Comorbidity Depression - diagnosis Depression - epidemiology Depression - psychology Depressive Disorder, Major - diagnosis Depressive Disorder, Major - epidemiology Depressive Disorder, Major - psychology Depressive symptoms Double-Blind Method Female Follow-Up Studies Health Status Humans Internal Medicine Male Middle Aged Placebos Psychiatric Status Rating Scales - statistics & numerical data Psychotic Disorders - diagnosis Psychotic Disorders - epidemiology Psychotic Disorders - psychology schizophrenia Schizophrenia - diagnosis Schizophrenia - epidemiology Schizophrenic Psychology Serotonin Uptake Inhibitors - therapeutic use subsyndromal depression Suicide - psychology Suicide - statistics & numerical data Treatment Outcome |
| title | Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia |
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