Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair

The partitioning-defective 3 (Par3), a key component in the conserved Par3/Par6/aPKC complex, plays fundamental roles in cell polarity. Herein we report the identification of Ku70 and Ku80 as novel Par3-interacting proteins through an in vitro binding assay followed by liquid chromatography-tandem m...

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Veröffentlicht in:	Cell research 2007-02, Vol.17 (2), p.100-116
Hauptverfasser:	Fang, Longhou, Wang, YiGuo, Du, Dan, Yang, Guang, Tak Kwok, Tim, Kai Kong, Siu, Chen, Benjamin, Chen, David J, Chen, Zhengjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear - physiology Biomedical and Life Sciences Caco-2 Cells Catalytic Domain - physiology Cell Biology Cell Cycle Proteins - physiology Cell Polarity - physiology Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA Repair - physiology DNA-Activated Protein Kinase - physiology DNA-Binding Proteins - physiology Gene Expression Regulation - physiology HeLa Cells Humans Irradiation Ku Autoantigen Life Sciences Liquid chromatography Mass spectrometry Membrane Proteins - physiology Nuclear Proteins - physiology original-article Proteins
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