Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects
Aims The contribution of homocysteine and group B vitamins in determining cardiovascular risk is debated. We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-c...
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| Veröffentlicht in: | European heart journal 2007-02, Vol.28 (4), p.484-491 |
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| creator | Vanuzzo, Diego Pilotto, Lorenza Lombardi, Rossana Lazzerini, Guido Carluccio, Marisa Diviacco, Silvia Quadrifoglio, Franco Danek, Giorgia Gregori, Dario Fioretti, Paolo Cattaneo, Marco De Caterina, Raffaele |
| description | Aims The contribution of homocysteine and group B vitamins in determining cardiovascular risk is debated. We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study.
Methods and results Within a cohort of 1021 healthy subjects (490 men and 531 women) recruited in 1987, 66 first-ever coronary and 43 first-ever cerebrovascular events were recorded at a 12-year follow-up (cases, n = 109). A total of 109 control subjects (remaining free from events) were matched with cases according to age, sex, smoking, hypertension, dyslipidaemia, and body mass index. Serum samples obtained in 1987 at baseline were used to measure tHcy, folate, and vitamins B12 and B6, as well as C-reactive protein plasma concentrations. We found a significant graded association between tHcy levels and the risk of coronary and cerebrovascular events [odds ratio (OR) for uppermost vs. lowermost quartile = 1.34, 95% CI 1.01-1.76)]. Folate and vitamin B12 did not significantly differ between cases and controls, but were negatively (P < 0.01) correlated with tHcy. Vitamin B6 did not correlate with tHcy levels, but differed significantly between cases and controls: for subjects in the uppermost quartile vs. the lowermost quartile of vitamin B6, OR = 0.69 (95% CI 0.49-0.98). For subjects in the lowermost quartile of vitamin B6 and the uppermost quartile of tHcy, OR = 17.50 (95% CI 1.97, 155.59). Cases and controls were not different as to C-reactive protein.
Conclusion tHcy and plasma vitamin B6 are long-term independent risk factors for coronary and cerebrovascular events. |
| doi_str_mv | 10.1093/eurheartj/ehl470 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69010609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurheartj/ehl470</oup_id><sourcerecordid>69010609</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-56da60fd253db7e06d9cb4dc83872d9a0bdc6442427a1be1c4e7e99cd38139853</originalsourceid><addsrcrecordid>eNqFkc9L5DAUx4MoOs5639MShPUi1aRN0uS4ir9A8OKCt5Imb7Yd0qYmqTD_vZEZVvDi6V0-7_O-vC9CPym5oERVlzCHDnRI60voHKvJHlpQXpaFEozvowWhihdCyJcjdBzjmhAiBRWH6IjWpagZVwsUrnzq8Fuf9NCP-EpgPVqcfNIOd37wZhMT9CPgyek4aOzgDVzEUwDbm4SdH_8VCcKAdeogZFXwQ-tTb3AGxxRxluaELnUbHOd2DSbFH-hgpV2Ek91cor-3N8_X98Xj093D9Z_HwjAlU8GF1YKsbMkr29ZAhFWmZdbIStalVZq01gjGSlbWmrZADYMalDK2krRSkldLdLb1TsG_zhBTM_TRgHN6BD_HRihCichvXKLTL-Daz2HM2ZqSck4ZqT5sZAuZ4GMMsGqm0A86bBpKmo8ymv9lNNsy8sqvnXduB7CfC7vvZ-D3DtDRaLcKejR9_OQkr6UiInPnW87P0_dn3wGAsqbf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215514035</pqid></control><display><type>article</type><title>Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Vanuzzo, Diego ; Pilotto, Lorenza ; Lombardi, Rossana ; Lazzerini, Guido ; Carluccio, Marisa ; Diviacco, Silvia ; Quadrifoglio, Franco ; Danek, Giorgia ; Gregori, Dario ; Fioretti, Paolo ; Cattaneo, Marco ; De Caterina, Raffaele</creator><creatorcontrib>Vanuzzo, Diego ; Pilotto, Lorenza ; Lombardi, Rossana ; Lazzerini, Guido ; Carluccio, Marisa ; Diviacco, Silvia ; Quadrifoglio, Franco ; Danek, Giorgia ; Gregori, Dario ; Fioretti, Paolo ; Cattaneo, Marco ; De Caterina, Raffaele</creatorcontrib><description>Aims The contribution of homocysteine and group B vitamins in determining cardiovascular risk is debated. We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study.
Methods and results Within a cohort of 1021 healthy subjects (490 men and 531 women) recruited in 1987, 66 first-ever coronary and 43 first-ever cerebrovascular events were recorded at a 12-year follow-up (cases, n = 109). A total of 109 control subjects (remaining free from events) were matched with cases according to age, sex, smoking, hypertension, dyslipidaemia, and body mass index. Serum samples obtained in 1987 at baseline were used to measure tHcy, folate, and vitamins B12 and B6, as well as C-reactive protein plasma concentrations. We found a significant graded association between tHcy levels and the risk of coronary and cerebrovascular events [odds ratio (OR) for uppermost vs. lowermost quartile = 1.34, 95% CI 1.01-1.76)]. Folate and vitamin B12 did not significantly differ between cases and controls, but were negatively (P < 0.01) correlated with tHcy. Vitamin B6 did not correlate with tHcy levels, but differed significantly between cases and controls: for subjects in the uppermost quartile vs. the lowermost quartile of vitamin B6, OR = 0.69 (95% CI 0.49-0.98). For subjects in the lowermost quartile of vitamin B6 and the uppermost quartile of tHcy, OR = 17.50 (95% CI 1.97, 155.59). Cases and controls were not different as to C-reactive protein.
Conclusion tHcy and plasma vitamin B6 are long-term independent risk factors for coronary and cerebrovascular events.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehl470</identifier><identifier>PMID: 17267459</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Case-Control Studies ; Coronary Artery Disease - blood ; Coronary Artery Disease - etiology ; Coronary heart disease ; Coronary Thrombosis - blood ; Coronary Thrombosis - etiology ; Female ; Heart ; Homocysteine - metabolism ; Humans ; Intracranial Arteriosclerosis - blood ; Intracranial Arteriosclerosis - etiology ; Intracranial Thrombosis - blood ; Intracranial Thrombosis - etiology ; Male ; Medical sciences ; Middle Aged ; Neurology ; Prospective Studies ; Risk Factors ; Stroke - blood ; Stroke - etiology ; Vascular diseases and vascular malformations of the nervous system ; Vitamin B 6 - metabolism</subject><ispartof>European heart journal, 2007-02, Vol.28 (4), p.484-491</ispartof><rights>The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2007</rights><rights>2007 INIST-CNRS</rights><rights>The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-56da60fd253db7e06d9cb4dc83872d9a0bdc6442427a1be1c4e7e99cd38139853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18578906$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17267459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanuzzo, Diego</creatorcontrib><creatorcontrib>Pilotto, Lorenza</creatorcontrib><creatorcontrib>Lombardi, Rossana</creatorcontrib><creatorcontrib>Lazzerini, Guido</creatorcontrib><creatorcontrib>Carluccio, Marisa</creatorcontrib><creatorcontrib>Diviacco, Silvia</creatorcontrib><creatorcontrib>Quadrifoglio, Franco</creatorcontrib><creatorcontrib>Danek, Giorgia</creatorcontrib><creatorcontrib>Gregori, Dario</creatorcontrib><creatorcontrib>Fioretti, Paolo</creatorcontrib><creatorcontrib>Cattaneo, Marco</creatorcontrib><creatorcontrib>De Caterina, Raffaele</creatorcontrib><title>Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims The contribution of homocysteine and group B vitamins in determining cardiovascular risk is debated. We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study.
Methods and results Within a cohort of 1021 healthy subjects (490 men and 531 women) recruited in 1987, 66 first-ever coronary and 43 first-ever cerebrovascular events were recorded at a 12-year follow-up (cases, n = 109). A total of 109 control subjects (remaining free from events) were matched with cases according to age, sex, smoking, hypertension, dyslipidaemia, and body mass index. Serum samples obtained in 1987 at baseline were used to measure tHcy, folate, and vitamins B12 and B6, as well as C-reactive protein plasma concentrations. We found a significant graded association between tHcy levels and the risk of coronary and cerebrovascular events [odds ratio (OR) for uppermost vs. lowermost quartile = 1.34, 95% CI 1.01-1.76)]. Folate and vitamin B12 did not significantly differ between cases and controls, but were negatively (P < 0.01) correlated with tHcy. Vitamin B6 did not correlate with tHcy levels, but differed significantly between cases and controls: for subjects in the uppermost quartile vs. the lowermost quartile of vitamin B6, OR = 0.69 (95% CI 0.49-0.98). For subjects in the lowermost quartile of vitamin B6 and the uppermost quartile of tHcy, OR = 17.50 (95% CI 1.97, 155.59). Cases and controls were not different as to C-reactive protein.
Conclusion tHcy and plasma vitamin B6 are long-term independent risk factors for coronary and cerebrovascular events.</description><subject>Adult</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary heart disease</subject><subject>Coronary Thrombosis - blood</subject><subject>Coronary Thrombosis - etiology</subject><subject>Female</subject><subject>Heart</subject><subject>Homocysteine - metabolism</subject><subject>Humans</subject><subject>Intracranial Arteriosclerosis - blood</subject><subject>Intracranial Arteriosclerosis - etiology</subject><subject>Intracranial Thrombosis - blood</subject><subject>Intracranial Thrombosis - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Stroke - blood</subject><subject>Stroke - etiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vitamin B 6 - metabolism</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9L5DAUx4MoOs5639MShPUi1aRN0uS4ir9A8OKCt5Imb7Yd0qYmqTD_vZEZVvDi6V0-7_O-vC9CPym5oERVlzCHDnRI60voHKvJHlpQXpaFEozvowWhihdCyJcjdBzjmhAiBRWH6IjWpagZVwsUrnzq8Fuf9NCP-EpgPVqcfNIOd37wZhMT9CPgyek4aOzgDVzEUwDbm4SdH_8VCcKAdeogZFXwQ-tTb3AGxxRxluaELnUbHOd2DSbFH-hgpV2Ek91cor-3N8_X98Xj093D9Z_HwjAlU8GF1YKsbMkr29ZAhFWmZdbIStalVZq01gjGSlbWmrZADYMalDK2krRSkldLdLb1TsG_zhBTM_TRgHN6BD_HRihCichvXKLTL-Daz2HM2ZqSck4ZqT5sZAuZ4GMMsGqm0A86bBpKmo8ymv9lNNsy8sqvnXduB7CfC7vvZ-D3DtDRaLcKejR9_OQkr6UiInPnW87P0_dn3wGAsqbf</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Vanuzzo, Diego</creator><creator>Pilotto, Lorenza</creator><creator>Lombardi, Rossana</creator><creator>Lazzerini, Guido</creator><creator>Carluccio, Marisa</creator><creator>Diviacco, Silvia</creator><creator>Quadrifoglio, Franco</creator><creator>Danek, Giorgia</creator><creator>Gregori, Dario</creator><creator>Fioretti, Paolo</creator><creator>Cattaneo, Marco</creator><creator>De Caterina, Raffaele</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects</title><author>Vanuzzo, Diego ; Pilotto, Lorenza ; Lombardi, Rossana ; Lazzerini, Guido ; Carluccio, Marisa ; Diviacco, Silvia ; Quadrifoglio, Franco ; Danek, Giorgia ; Gregori, Dario ; Fioretti, Paolo ; Cattaneo, Marco ; De Caterina, Raffaele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-56da60fd253db7e06d9cb4dc83872d9a0bdc6442427a1be1c4e7e99cd38139853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary heart disease</topic><topic>Coronary Thrombosis - blood</topic><topic>Coronary Thrombosis - etiology</topic><topic>Female</topic><topic>Heart</topic><topic>Homocysteine - metabolism</topic><topic>Humans</topic><topic>Intracranial Arteriosclerosis - blood</topic><topic>Intracranial Arteriosclerosis - etiology</topic><topic>Intracranial Thrombosis - blood</topic><topic>Intracranial Thrombosis - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Stroke - blood</topic><topic>Stroke - etiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vitamin B 6 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanuzzo, Diego</creatorcontrib><creatorcontrib>Pilotto, Lorenza</creatorcontrib><creatorcontrib>Lombardi, Rossana</creatorcontrib><creatorcontrib>Lazzerini, Guido</creatorcontrib><creatorcontrib>Carluccio, Marisa</creatorcontrib><creatorcontrib>Diviacco, Silvia</creatorcontrib><creatorcontrib>Quadrifoglio, Franco</creatorcontrib><creatorcontrib>Danek, Giorgia</creatorcontrib><creatorcontrib>Gregori, Dario</creatorcontrib><creatorcontrib>Fioretti, Paolo</creatorcontrib><creatorcontrib>Cattaneo, Marco</creatorcontrib><creatorcontrib>De Caterina, Raffaele</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanuzzo, Diego</au><au>Pilotto, Lorenza</au><au>Lombardi, Rossana</au><au>Lazzerini, Guido</au><au>Carluccio, Marisa</au><au>Diviacco, Silvia</au><au>Quadrifoglio, Franco</au><au>Danek, Giorgia</au><au>Gregori, Dario</au><au>Fioretti, Paolo</au><au>Cattaneo, Marco</au><au>De Caterina, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>28</volume><issue>4</issue><spage>484</spage><epage>491</epage><pages>484-491</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims The contribution of homocysteine and group B vitamins in determining cardiovascular risk is debated. We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study.
Methods and results Within a cohort of 1021 healthy subjects (490 men and 531 women) recruited in 1987, 66 first-ever coronary and 43 first-ever cerebrovascular events were recorded at a 12-year follow-up (cases, n = 109). A total of 109 control subjects (remaining free from events) were matched with cases according to age, sex, smoking, hypertension, dyslipidaemia, and body mass index. Serum samples obtained in 1987 at baseline were used to measure tHcy, folate, and vitamins B12 and B6, as well as C-reactive protein plasma concentrations. We found a significant graded association between tHcy levels and the risk of coronary and cerebrovascular events [odds ratio (OR) for uppermost vs. lowermost quartile = 1.34, 95% CI 1.01-1.76)]. Folate and vitamin B12 did not significantly differ between cases and controls, but were negatively (P < 0.01) correlated with tHcy. Vitamin B6 did not correlate with tHcy levels, but differed significantly between cases and controls: for subjects in the uppermost quartile vs. the lowermost quartile of vitamin B6, OR = 0.69 (95% CI 0.49-0.98). For subjects in the lowermost quartile of vitamin B6 and the uppermost quartile of tHcy, OR = 17.50 (95% CI 1.97, 155.59). Cases and controls were not different as to C-reactive protein.
Conclusion tHcy and plasma vitamin B6 are long-term independent risk factors for coronary and cerebrovascular events.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17267459</pmid><doi>10.1093/eurheartj/ehl470</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels C-Reactive Protein - metabolism Cardiology. Vascular system Case-Control Studies Coronary Artery Disease - blood Coronary Artery Disease - etiology Coronary heart disease Coronary Thrombosis - blood Coronary Thrombosis - etiology Female Heart Homocysteine - metabolism Humans Intracranial Arteriosclerosis - blood Intracranial Arteriosclerosis - etiology Intracranial Thrombosis - blood Intracranial Thrombosis - etiology Male Medical sciences Middle Aged Neurology Prospective Studies Risk Factors Stroke - blood Stroke - etiology Vascular diseases and vascular malformations of the nervous system Vitamin B 6 - metabolism |
| title | Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects |
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