Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects
Purpose To compare two methods for assessing the single kidney glomerular filtration rate (SK‐GFR) in humans using dynamic contrast‐enhanced (DCE)‐MRI. Materials and Methods Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the k...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2006-11, Vol.24 (5), p.1117-1123 |
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| creator | Buckley, David L. Shurrab, Ala'a E. Cheung, Ching M. Jones, Andrew P. Mamtora, Hari Kalra, Philip A. |
| description | Purpose
To compare two methods for assessing the single kidney glomerular filtration rate (SK‐GFR) in humans using dynamic contrast‐enhanced (DCE)‐MRI.
Materials and Methods
Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland‐Patlak plot and a compartmental model. MR estimates of the SK‐GFR were compared with standard radioisotope measures in a total of 75 kidneys.
Results
Estimates of renal function using both techniques correlated well with radioisotope‐assessed SK‐GFR (Spearman's ρ = 0.81, Rutland‐Patlak; ρ = 0.71, compartmental model). The Rutland‐Patlak approach provided a near one‐to‐one correspondence, while the compartmental method tended to overestimate SK‐GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland‐Patlak approach.
Conclusion
DCE‐MRI of the kidneys provides data that correlate well with reference measures of SK‐GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.20699 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69010267</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69010267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4989-be2322560cb99b646444e758e8e46142c3b1d557a8a7770fe31f4ed1cf0ff6353</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EoqVw4QcgnzggpfjbMTcUQVvUhYoPcbQcZ0K9TZytHavdf0-WXeAGpxmNnnmkmReh55ScUkLY6_WYwikjypgH6JhKxioma_Vw6YnkFa2JPkJPcl4TQowR8jE6osoIqog6RmUFLpcEI8QZTz3OIf4YAN-ELsIW9yX6OUwRl90cd9voxuCxn-KcXJ4riNcueujw6vPFG9xM48alkBd-Mc13Ex6nDoaMQ8TXZXQR59Kuwc_5KXrUuyHDs0M9Qd_ev_vanFeXn84umreXlRemNlULjDMmFfGtMa0SSggBWtZQg1BUMM9b2kmpXe201qQHTnsBHfU96XvFJT9BL_feTZpuC-TZjiF7GAYXYSrZKkMoYUr_F6RG1ZzUO-OrPejTlHOC3m5SGF3aWkrsLg27S8P-SmOBXxyspR2h-4se3r8AdA_chQG2_1DZD8uHf0ur_U7IM9z_2XHpxi6HaGm_fzyzV1fNF6GbleX8J_HDpUE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19683085</pqid></control><display><type>article</type><title>Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Buckley, David L. ; Shurrab, Ala'a E. ; Cheung, Ching M. ; Jones, Andrew P. ; Mamtora, Hari ; Kalra, Philip A.</creator><creatorcontrib>Buckley, David L. ; Shurrab, Ala'a E. ; Cheung, Ching M. ; Jones, Andrew P. ; Mamtora, Hari ; Kalra, Philip A.</creatorcontrib><description>Purpose
To compare two methods for assessing the single kidney glomerular filtration rate (SK‐GFR) in humans using dynamic contrast‐enhanced (DCE)‐MRI.
Materials and Methods
Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland‐Patlak plot and a compartmental model. MR estimates of the SK‐GFR were compared with standard radioisotope measures in a total of 75 kidneys.
Results
Estimates of renal function using both techniques correlated well with radioisotope‐assessed SK‐GFR (Spearman's ρ = 0.81, Rutland‐Patlak; ρ = 0.71, compartmental model). The Rutland‐Patlak approach provided a near one‐to‐one correspondence, while the compartmental method tended to overestimate SK‐GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland‐Patlak approach.
Conclusion
DCE‐MRI of the kidneys provides data that correlate well with reference measures of SK‐GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.20699</identifier><identifier>PMID: 16941606</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Algorithms ; Computer Simulation ; Contrast Media ; Female ; gadolinium ; Gadolinium DTPA - metabolism ; Gadolinium DTPA - pharmacokinetics ; glomerular filtration ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; kidney ; Kidney - pathology ; Kidney - physiopathology ; Kidney Diseases - diagnosis ; Kidney Diseases - physiopathology ; Kidney Function Tests - methods ; Kinetics ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Models, Biological ; perfusion ; renovascular disease ; Reproducibility of Results ; Sensitivity and Specificity ; tracer kinetics</subject><ispartof>Journal of magnetic resonance imaging, 2006-11, Vol.24 (5), p.1117-1123</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>Copyright (c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4989-be2322560cb99b646444e758e8e46142c3b1d557a8a7770fe31f4ed1cf0ff6353</citedby><cites>FETCH-LOGICAL-c4989-be2322560cb99b646444e758e8e46142c3b1d557a8a7770fe31f4ed1cf0ff6353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.20699$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.20699$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27931,27932,45581,45582,46416,46840</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16941606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buckley, David L.</creatorcontrib><creatorcontrib>Shurrab, Ala'a E.</creatorcontrib><creatorcontrib>Cheung, Ching M.</creatorcontrib><creatorcontrib>Jones, Andrew P.</creatorcontrib><creatorcontrib>Mamtora, Hari</creatorcontrib><creatorcontrib>Kalra, Philip A.</creatorcontrib><title>Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To compare two methods for assessing the single kidney glomerular filtration rate (SK‐GFR) in humans using dynamic contrast‐enhanced (DCE)‐MRI.
Materials and Methods
Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland‐Patlak plot and a compartmental model. MR estimates of the SK‐GFR were compared with standard radioisotope measures in a total of 75 kidneys.
Results
Estimates of renal function using both techniques correlated well with radioisotope‐assessed SK‐GFR (Spearman's ρ = 0.81, Rutland‐Patlak; ρ = 0.71, compartmental model). The Rutland‐Patlak approach provided a near one‐to‐one correspondence, while the compartmental method tended to overestimate SK‐GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland‐Patlak approach.
Conclusion
DCE‐MRI of the kidneys provides data that correlate well with reference measures of SK‐GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Computer Simulation</subject><subject>Contrast Media</subject><subject>Female</subject><subject>gadolinium</subject><subject>Gadolinium DTPA - metabolism</subject><subject>Gadolinium DTPA - pharmacokinetics</subject><subject>glomerular filtration</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>kidney</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - diagnosis</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kidney Function Tests - methods</subject><subject>Kinetics</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>perfusion</subject><subject>renovascular disease</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>tracer kinetics</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EoqVw4QcgnzggpfjbMTcUQVvUhYoPcbQcZ0K9TZytHavdf0-WXeAGpxmNnnmkmReh55ScUkLY6_WYwikjypgH6JhKxioma_Vw6YnkFa2JPkJPcl4TQowR8jE6osoIqog6RmUFLpcEI8QZTz3OIf4YAN-ELsIW9yX6OUwRl90cd9voxuCxn-KcXJ4riNcueujw6vPFG9xM48alkBd-Mc13Ex6nDoaMQ8TXZXQR59Kuwc_5KXrUuyHDs0M9Qd_ev_vanFeXn84umreXlRemNlULjDMmFfGtMa0SSggBWtZQg1BUMM9b2kmpXe201qQHTnsBHfU96XvFJT9BL_feTZpuC-TZjiF7GAYXYSrZKkMoYUr_F6RG1ZzUO-OrPejTlHOC3m5SGF3aWkrsLg27S8P-SmOBXxyspR2h-4se3r8AdA_chQG2_1DZD8uHf0ur_U7IM9z_2XHpxi6HaGm_fzyzV1fNF6GbleX8J_HDpUE</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Buckley, David L.</creator><creator>Shurrab, Ala'a E.</creator><creator>Cheung, Ching M.</creator><creator>Jones, Andrew P.</creator><creator>Mamtora, Hari</creator><creator>Kalra, Philip A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects</title><author>Buckley, David L. ; Shurrab, Ala'a E. ; Cheung, Ching M. ; Jones, Andrew P. ; Mamtora, Hari ; Kalra, Philip A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4989-be2322560cb99b646444e758e8e46142c3b1d557a8a7770fe31f4ed1cf0ff6353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Algorithms</topic><topic>Computer Simulation</topic><topic>Contrast Media</topic><topic>Female</topic><topic>gadolinium</topic><topic>Gadolinium DTPA - metabolism</topic><topic>Gadolinium DTPA - pharmacokinetics</topic><topic>glomerular filtration</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>kidney</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - diagnosis</topic><topic>Kidney Diseases - physiopathology</topic><topic>Kidney Function Tests - methods</topic><topic>Kinetics</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>perfusion</topic><topic>renovascular disease</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>tracer kinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buckley, David L.</creatorcontrib><creatorcontrib>Shurrab, Ala'a E.</creatorcontrib><creatorcontrib>Cheung, Ching M.</creatorcontrib><creatorcontrib>Jones, Andrew P.</creatorcontrib><creatorcontrib>Mamtora, Hari</creatorcontrib><creatorcontrib>Kalra, Philip A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buckley, David L.</au><au>Shurrab, Ala'a E.</au><au>Cheung, Ching M.</au><au>Jones, Andrew P.</au><au>Mamtora, Hari</au><au>Kalra, Philip A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2006-11</date><risdate>2006</risdate><volume>24</volume><issue>5</issue><spage>1117</spage><epage>1123</epage><pages>1117-1123</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To compare two methods for assessing the single kidney glomerular filtration rate (SK‐GFR) in humans using dynamic contrast‐enhanced (DCE)‐MRI.
Materials and Methods
Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland‐Patlak plot and a compartmental model. MR estimates of the SK‐GFR were compared with standard radioisotope measures in a total of 75 kidneys.
Results
Estimates of renal function using both techniques correlated well with radioisotope‐assessed SK‐GFR (Spearman's ρ = 0.81, Rutland‐Patlak; ρ = 0.71, compartmental model). The Rutland‐Patlak approach provided a near one‐to‐one correspondence, while the compartmental method tended to overestimate SK‐GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland‐Patlak approach.
Conclusion
DCE‐MRI of the kidneys provides data that correlate well with reference measures of SK‐GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16941606</pmid><doi>10.1002/jmri.20699</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Algorithms Computer Simulation Contrast Media Female gadolinium Gadolinium DTPA - metabolism Gadolinium DTPA - pharmacokinetics glomerular filtration Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods kidney Kidney - pathology Kidney - physiopathology Kidney Diseases - diagnosis Kidney Diseases - physiopathology Kidney Function Tests - methods Kinetics Magnetic Resonance Imaging - methods Male Middle Aged Models, Biological perfusion renovascular disease Reproducibility of Results Sensitivity and Specificity tracer kinetics |
| title | Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects |
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