Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism

Tanshinone IIA (Tan IIA) is isolated from Salvia miltiorrhiza, the root of which is widely used as a traditional Chinese medicine to treat atherosclerosis. The aim of the present study was to evaluate the putative protective effect of Tan IIA in a human umbilical vein endothelial cell line (ECV-304)...

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Veröffentlicht in:	Journal of ethnopharmacology 2006-11, Vol.108 (2), p.217-222
Hauptverfasser:	Lin, Rong, Wang, Wei-Rong, Liu, Jun-Tian, Yang, Guang-De, Han, Chun-Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology antioxidants Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences CD40 CD40 Antigens - metabolism Cell Line Cell Survival - drug effects chemical constituents of plants Diterpenes, Abietane Dose-Response Relationship, Drug endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology ethnobotany Flow Cytometry - methods General pharmacology herbal medicines human cell lines Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Medical sciences medicinal plants medicinal properties Methanol Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenanthrenes - chemistry Phenanthrenes - isolation & purification Phenanthrenes - pharmacology plant extracts Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots - chemistry roots Salvia miltiorrhiza Salvia miltiorrhiza - chemistry Superoxide Dismutase - metabolism Tanshinone IIA Time Factors umbilical veins Umbilical Veins - drug effects Umbilical Veins - metabolism Umbilical Veins - pathology Water
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