Heat Shock Proteins 70 and 90 Inhibit Early Stages of Amyloid β-(1–42) Aggregation in Vitro

Alzheimer disease is a neurological disorder that is characterized by the presence of fibrils and oligomers composed of the amyloid β (Aβ) peptide. In models of Alzheimer disease, overexpression of molecular chaperones, specifically heat shock protein 70 (Hsp70), suppresses phenotypes related to Aβ...

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Veröffentlicht in:	The Journal of biological chemistry 2006-11, Vol.281 (44), p.33182-33191
Hauptverfasser:	Evans, Christopher G., Wisén, Susanne, Gestwicki, Jason E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - ultrastructure HSP40 Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - agonists HSP70 Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - ultrastructure HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - ultrastructure Humans Microscopy, Electron, Transmission Peptide Fragments - metabolism Peptide Fragments - ultrastructure Protein Binding Recombinant Proteins - genetics Recombinant Proteins - metabolism Time Factors
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